Trends in the Treatment of Metastatic Colon and Rectal Cancer in Elderly Patients

Medical Care
Cathy J BradleyElizabeth B Lamont

Abstract

Little is known about the use and costs of antineoplastic regimens for elderly patients with metastatic colorectal cancer (mCRC). We report population-based trends over a 10-year period in the treatment, survival, and costs in mCRC patients, stratified by ages 65-74 and 75+. We used Surveillance, Epidemiology, and End Results-Medicare data for persons diagnosed with metastatic colon (N=16117) or rectal cancer (N=4008) between 2000 and 2009. We estimated the adjusted percent of patients who received antineoplastic agents, by type, number, and their costs 12 months following diagnosis. We report the percent of patients who received 3 or more of commonly prescribed agents and estimate survival for the 24-month period following diagnosis by age and treatment. The percentage that received 3 or more agents increased from 3% to 73% in colon patients aged 65-74 and from 2% to 53% in patients 75+. Similar increases were observed in rectal patients. Average 1-year costs per patient in 2009 were $106,461 and $102,680 for colon and rectal cancers, respectively, reflecting an increase of 32% and 20%, for patients who received antineoplastic agents. Median survival increased by about 6 and 10 months, respectively, for colon and rectal patien...Continue Reading

References

Jun 24, 1999·Journal of the National Cancer Institute·B I Graubard, E L Korn
Sep 28, 2000·The New England Journal of Medicine·L B SaltzL L Miller
Oct 17, 2003·British Journal of Cancer·T AparicioUNKNOWN AGEO
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Mar 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gunnar FolprechtClaus-Henning Köhne
May 1, 2008·Journal of the National Cancer Institute·K Robin YabroffMartin L Brown
Jun 12, 2008·Journal of the National Cancer Institute·Joan L WarrenMartin L Brown
Jan 30, 2009·The New England Journal of Medicine·Peter B Bach
Jan 14, 2011·Journal of the National Cancer Institute·Angela B MariottoMartin L Brown
Nov 15, 2011·Medical Care·Jennifer L LundJoan L Warren
Jan 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A MeyerhardtDeborah Schrag
Feb 15, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stuart M Lichtman
Apr 12, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lowell E SchnipperDana S Wollins
Oct 30, 2012·Clinical Colorectal Cancer·Nadine Jackson McClearyJeffrey A Meyerhardt
Jun 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nadine J McClearyDaniel J Sargent
Sep 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dawn L HershmanAlfred I Neugut
Dec 4, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L LoprinziAxel Grothey
Feb 8, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C F JehnD Lüftner
Feb 11, 2014·Journal of the National Cancer Institute·Thomas A AbramsCharles S Fuchs
May 7, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J O'ConnellNorman Wolmark
Sep 3, 2014·Journal of the National Cancer Institute·Antonino BrunoDouglas M Noonan
Feb 1, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maria Di BartolomeoEmilio Bajetta
Jun 24, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lowell E Schnipper American Society of Clinical Oncology

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Citations

Oct 22, 2016·Journal of the National Cancer Institute·Cheryl K AlticeK Robin Yabroff
Nov 9, 2017·The Journal of Urology·Matthew Mossanen, Angela B Smith
Jan 11, 2019·Expert Review of Pharmacoeconomics & Outcomes Research·Arijeet Sensharma, K Robin Yabroff
Nov 2, 2019·Journal of the National Cancer Institute·K Robin YabroffCarrie N Klabunde
Aug 23, 2016·Medical Care·Cathy J BradleyElizabeth B Lamont
May 16, 2020·Journal of the National Cancer Institute. Monographs·Angela B MariottoK Robin Yabroff
May 16, 2020·Journal of the National Cancer Institute. Monographs·Clara J K LamAngela B Mariotto
Jul 24, 2018·ANZ Journal of Surgery·Aashray K GuptaMarkus I Trochsler
Feb 21, 2019·CA: a Cancer Journal for Clinicians·K Robin YabroffOtis W Brawley
Apr 29, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ian OlverCarla I Ripamonti
Nov 24, 2017·The Korean Journal of Internal Medicine·Yun Hwa JungIn Sook Woo
Jul 31, 2018·British Journal of Cancer·Yvette H M ClaassenEsther Bastiaannet
Aug 2, 2016·Medical Care·Kristin LinkeTimothy J Price
Oct 20, 2020·Expert Opinion on Investigational Drugs·Sreenivasa R ChandanaDaruka Mahadevan
Jun 12, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Angela B MariottoK Robin Yabroff
Nov 16, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·K Robin YabroffXuesong Han
Feb 8, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Thomas AparicioElena Paillaud

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