Trends in thyroid cancer: Retrospective analysis of incidence and survival in Denmark 1980-2014

Cancer Epidemiology
Christian MirianChristian von Buchwald

Abstract

Thyroid cancer incidence has been reported to be increasing since the 1970 s. The aim of this study was to investigate the change in incidence and survival from 1980 to 2014 in Denmark. We identified patients registered with thyroid cancer in the period 1980-2014. We evaluated the age-adjusted incidence rate (AAIR) and the average annual percentage change (AAPC), constructed age-period-cohort models (APCs), and evaluated relative survival (RS). We included 5139 patients. The AAIR was 1.6 cases per 100,000 in 1980 and 4.5 cases in 2014 with an AAPC of 3.4%. The AAIR for papillary carcinomas (n = 2864) quintupled in the study period, and accounts for most of the observed increase in incidence with an AAPC of 4.9%. Follicular carcinomas (n = 920) nearly tripled in AAIR and had the second greatest increase in AAPC. Papillary carcinomas had the best prognosis with 1-year and 5-year RSs of 95% and 91%, followed by the follicular carcinomas with 1-year and 5-year RSs of 90% and 80%, respectively. Anaplastic carcinomas (n = 320) had the worst prognosis with 1-year and 5-year RSs of 18% and 12%. We found a significant age effect in the APC model for the incidence of thyroid cancer but no significant cohort or period effects. The inciden...Continue Reading

Citations

May 24, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Jeffrey C RastatterGregory W Randolph
Dec 22, 2019·International Journal of Molecular Sciences·Ole Vincent AnckerDaniela Grimm
Aug 7, 2019·Dose-response : a Publication of International Hormesis Society·Feng ShiRuixue Huang
Dec 22, 2020·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·R SawantI J Nixon
Oct 16, 2020·Acta Oncologica·Kathrine Kronberg JakobsenChristian Grønhøj
Apr 11, 2021·Tropical Medicine & International Health : TM & IH·Fábia Cheyenne Gomes de Morais FernandesIsabelle Ribeiro Barbosa
Sep 20, 2020·Cancer Letters·Jun CaoMeiyu Fang
Nov 27, 2019·European Thyroid Journal·Signe Buhl GramChristoffer Holst Hahn

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