Trends in transfusion rates after the FOCUS trial

Journal of Comparative Effectiveness Research
David H HowardDavid J Murphy

Abstract

We estimate the impact of the FOCUS trial, which concluded that hip surgery patients with hemoglobin values above 8 g/dl do not benefit from routine transfusions, on transfusion rates. We evaluated trends in transfusion rates using inpatient discharge data from four states. The transfusion rate was 5.2 percentage points lower in the fourth quarter of 2013 than it would have been had pre-FOCUS trends continued. Transfusion rates declined more in hospitals with a low end-of-life treatment intensity index, a general measure of treatment intensity. The FOCUS trial affected practice, but there are additional opportunities to reduce the use of transfusions.

References

Feb 7, 1998·Medical Care·A ElixhauserR M Coffey
Feb 2, 1993·The Journal of Economic Perspectives : a Journal of the American Economic Association·C E Phelps
Apr 24, 2001·Transfusion·J B SegalN R Powe
Mar 21, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jennifer L BeaumontElizabeth A Hahn
Oct 14, 2010·JAMA : the Journal of the American Medical Association·Ludhmila A HajjarJose O C Auler
Dec 16, 2011·The New England Journal of Medicine·Jeffrey L CarsonUNKNOWN FOCUS Investigators
Jan 5, 2012·JAMA : the Journal of the American Medical Association·Vinay PrasadJohn P A Ioannidis
Jul 4, 2012·Annals of Internal Medicine·Jeffrey L CarsonUNKNOWN Clinical Transfusion Medicine Committee of the AABB
Apr 3, 2014·JAMA : the Journal of the American Medical Association·Jeffrey M RohdeMary A M Rogers
May 2, 2014·Annals of Internal Medicine·Benjamin R Roman, David A Asch
May 7, 2014·Health Services Research·Bryan E DowdEdward C Norton
Sep 23, 2016·Transfusion Medicine·D H HowardJ D Roback

❮ Previous
Next ❯

Citations

Mar 8, 2019·Health Services Research·David H Howard, Jason Hockenberry
Aug 27, 2019·Critical Care Medicine·Casey A CableDavid J Murphy
Feb 1, 2020·Current Opinion in Anaesthesiology·Aryeh ShanderDonat R Spahn

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nursing Mirror and Midwives Journal
M S Wright
Australian Health Review : a Publication of the Australian Hospital Association
Ken M Hillman
Clinical Medicine : Journal of the Royal College of Physicians of London
Simon Conroy
© 2022 Meta ULC. All rights reserved