Trends in treatments of thyroid disease following iodine fortification in Denmark: a nationwide register-based study

Clinical Epidemiology
Line Tang MøllehaveBetina Heinsbæk Thuesen

Abstract

Long-term iodine exposure may influence the frequency of thyroid disease treatments through fluctuations in thyroid diseases. Yet, the long-term fluctuations in thyroid disease treatments upon iodine fortification (IF) are not fully known. We aimed to examine the development in thyroid disease treatments in Denmark before and following the implementation of IF in 2000. Nationwide data on antithyroid medication, thyroid hormone therapy, thyroid surgery, and radioiodine treatment were obtained from Danish registries. Negative binominal regression was applied to analyze annual changes in treatment rates adjusted for region of residence, sex, and age. Incidence of antithyroid medication transiently increased but fell and reached steady state from 2010 at an incidence rate ratio (RR) of 0.72 (95% confidence interval [CI] 0.67-0.77) compared to year 2000. Thyroid hormone therapy increased and reached steady state in 2010 at an incidence RR of 1.75 (95% CI 1.62-1.89) compared to year 2000. Thyroid surgery was constant except for higher rates in 2014-2015, and radioiodine treatment fluctuated with no apparent pattern. Ten years after IF, a steady state was observed for incident antithyroid medication below the level at IF, and thyroid ...Continue Reading

Citations

Oct 17, 2019·Nature Reviews. Endocrinology·Jina KimSanziana A Roman
Dec 15, 2018·The Journal of Clinical Endocrinology and Metabolism·Mads PetersenInge Bülow Pedersen
Aug 11, 2019·Clinical Endocrinology·Mads PetersenAllan Carlé
Jan 30, 2021·Clinical Endocrinology·Line Tang MøllehaveBetina Heinsbaek Thuesen

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