Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions

Endocrine Research
N MachairasG Kouraklis

Abstract

Carcinogenesis has been related to systematic inflammatory response. Our aim was to study white blood cell and platelet indices as markers of this inflammatory response in thyroid cancer and to associate them with various clinicopathological parameters. We included 228 patients who underwent thyroidectomy within a period of 54 months, 89 with papillary thyroid carcinoma and 139 with multinodular hyperplasia. We examined potential links between white blood cell and platelet indices on the one hand and the type thyroid pathology and various clinicopathological parameters on the other. No significant differences were detected between thyroid cancer and multinodular hyperplasia and no significant associations were detected with regard to lymphovascular invasion and tumor size. However, the mean platelet volume was higher in multifocal tumors, while the platelet count, plateletcrit, and platelet-to-lymphocyte ratio were increased in cases with extrathyroidal extension and in T3 tumors. Additionally, T3 tumors had lower platelet distribution width. These associations demonstrated low accuracy in predicting these pathological features, but they were found to provide a satisfying negative predictive value, with the exception of the mea...Continue Reading

References

Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jan 7, 2006·Nature Reviews. Cancer·Karin E de VisserLisa M Coussens
Mar 3, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Barrett J Rollins
Apr 11, 2006·Molecular Cancer Research : MCR·Haitian LuChuanshu Huang
May 20, 2008·Mutation Research·Joydeb Kumar Kundu, Young-Joon Surh
Sep 30, 2010·Journal of Cancer Research and Clinical Oncology·Ying WuYulan Zhao
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S CedrésE Felip
Sep 12, 2012·Journal of Translational Medicine·Nina MikirovaPaul Taylor
Sep 22, 2012·Journal of Surgical Oncology·Chien-Liang LiuShih-Ping Cheng
Dec 18, 2013·Magyar sebészet·Zsolt BaranyaiZoltán Szállási
Feb 26, 2014·World Journal of Gastrointestinal Oncology·Ioannis A Voutsadakis
Apr 4, 2014·Cancer Metastasis Reviews·David G MenterKenneth V Honn
May 6, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Arnoud J TempletonEitan Amir
Apr 7, 2015·Annals of Surgical Treatment and Research·Jin-Seong ChoJung-Han Yoon
Apr 10, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Suleyman BaldaneLevent Kebapcilar
Apr 22, 2015·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Jifeng LiuChao Li
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Derya KocerFahri Bayram
Jun 17, 2015·Virchows Archiv : an International Journal of Pathology·Nicolas A GiraldoWolf H Fridman
Jul 21, 2015·Biochimica Et Biophysica Acta·MengJie Yan, Paul Jurasz
May 26, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Selcuk YaylaciCeyhun Varim
Jul 16, 2016·Nature Reviews. Endocrinology·Cari M Kitahara, Julie A Sosa

❮ Previous
Next ❯

Citations

Jan 26, 2020·Journal of Viral Hepatitis·Jian WangChao Wu
Aug 16, 2019·International Journal of Molecular Sciences·Gilda VarricchiMaria Rosaria Galdiero
Apr 11, 2021·The Journal of Clinical Endocrinology and Metabolism·Pedro MarquesAlberto M Pereira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.