Trends of non-union and prescriptions for non-steroidal anti-inflammatory drugs in the United States, 1993-2012

Acta Orthopaedica
Zhong Wang, Timothy Bhattacharyya

Abstract

Background and purpose - Surgical care and pain management for patients with fractures have evolved over the years. We wanted to ascertain if there were any changes in the incidence of non-unions and, if so, whether the use of non-steroidal anti-inflammatory drugs (NSAIDs), including COX-2 selective inhibitors, might have an effect. Patients and methods - We used the National Inpatient Sample (NIS) to estimate the annual number of patients hospitalized for surgical treatment of a non-union between 1993 and 2012, and calculated age-adjusted rates of non-union. We estimated the prevalence of prescriptions for NSAIDs from 1996 through 2012 using the Medical Expenditure Panel Survey (MEPS). The interrupted time-series analysis was used to relate quarterly rates of non-union to changes in prescriptions for NSAIDs between 1996 and 2009. Results - The annual estimate of non-unions in the USA declined 30% from 25,634 in 1993 to 17,815 in 2012 (p < 0.001). Specifically, the age-adjusted rate of non-unions decreased by 44% from 8.6 per 10(5) persons in 1996 to 4.8 per 10(5) persons in 2012 (p < 0.001). However, there was an 8% increase in the incidence rate of non-unions (p = 0.003) between 2000 and 2004, when certain COX-2 selective inh...Continue Reading

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Citations

May 27, 2020·The Journal of Bone and Joint Surgery. American Volume·Michael D GeorgeSean Hennessy
Jul 18, 2020·The Journal of Bone and Joint Surgery. American Volume·Michael D GeorgeSean Hennessy
Jul 20, 2019·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Arya NielsenUNKNOWN Consortium Pain Task Force
May 22, 2020·Current Rheumatology Reports·Hossein BonakdariJohanne Martel-Pelletier
May 8, 2018·Explore : the Journal of Science and Healing·Heather TickUNKNOWN Pain Task Force of the Academic Consortium for Integrative Medicine and Health

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