Trends of resistance to antimicrobials recommended currently and in the past for management of gonorrhea in the Apex STD center in India and comparison of antimicrobial resistance profile between 2002-2006 and 2007-2012

Sexually Transmitted Diseases
M BalaV Ramesh

Abstract

Antimicrobial resistance in Neisseria gonorrhoeae jeopardizes public health and continues to spread out to currently recommended and older antimicrobial agents. Antimicrobial resistance (AMR) surveillance provides essential clues toward the modification of treatment guidelines. The aim of the study was to determine gonococcal AMR profile and trends between 2007 and 2012 and to evaluate any change in AMR profile in comparison with published trends in 2002 to 2006. Antimicrobial susceptibility testing of 261 N. gonorrhoeae isolates from consecutive patients between 2007 and 2012 was determined for penicillin, tetracycline, ciprofloxacin, spectinomycin, extended-spectrum cephalosporins (ceftriaxone, cefixime, cefpodoxime) and azithromycin by the disk diffusion technique and the Etest method. P value was determined using χ test for comparisons of trends between the 2 periods. In comparison of AMR trends between 2002-2006 and 2007-2012, penicillinase-producing N. gonorrhoeae, tetracycline-resistant N. gonorrhoeae, and ciprofloxacin-resistant strains increased significantly from 21.2% to 47.9% (P < 0.0001), 13.6% to 25.3% (P = 0.0002), and 78% to 89.7% (P = 0.0001), respectively. An insignificant increase from 2.4% to 4.2% (P > 0.05)...Continue Reading

References

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Citations

Aug 9, 2016·Tropical Medicine & International Health : TM & IH·S DivyashreeP Rupali
Nov 1, 2016·Antimicrobial Agents and Chemotherapy·Manju BalaRavi Bhatnagar
Dec 3, 2016·Antimicrobial Resistance and Infection Control·Hsi LiuDavid Trees
Jan 13, 2017·Sexually Transmitted Diseases·Aradhana BhargavaAshok Kumar Saxena
Dec 13, 2017·Journal of Medical Microbiology·Sangeeta V KulkarniSheela V Godbole
Aug 8, 2018·Indian Journal of Medical Microbiology·Mohit SharmaIndu Shukla

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