Trends of testing for and diagnosis of α1 -antitrypsin deficiency in the UK: more testing is needed

The European Respiratory Journal
Joan B SorianoRespiratory Effectiveness Group

Abstract

α1-antitrypsin deficiency (AATD) significantly increases the risk of developing chronic obstructive pulmonary disease (COPD), and testing of all COPD patients for AATD is recommended by the World Health Organization, European Respiratory Society and Global Initiative for Chronic Obstructive Lung Disease (GOLD). We aimed to determine trends for testing and diagnosing AATD from 1990 to 2014.This study analysed all patients diagnosed with COPD from about 550 UK Optimum Patient Care Research Database general practices, including a subgroup of those diagnosed before the age of 60 years.We identified 107 024 COPD individuals, of whom 29 596 (27.6%) were diagnosed before 60 years of age. Of them, only 2.2% (95% CI 2.09-2.43%) had any record of being tested for AATD. Of those tested, 23.7% (95% CI 20.5-27.1%) were diagnosed with AATD. Between 1994 and 2013 the incidence of AATD diagnosis generally increased. A diagnosis of AATD was associated with being male, being an ex-smoker, more severe COPD with a lower forced expiratory volume in 1 s % pred and higher GOLD 2017 stages (all p<0.05).Despite an increase in the frequency of AATD testing since 1990, only 2.2% of patients diagnosed with COPD before the age of 60 years were tested. AATD...Continue Reading

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Citations

Dec 24, 2018·The European Respiratory Journal·Joan B Soriano, UNKNOWN all co-authors
Jun 11, 2019·Drugs & Aging·Diana CrossleyElizabeth Sapey
Feb 8, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jack DummerAnne E Holland
Sep 29, 2020·ERJ Open Research·Marlies van DijkMarieke L Duiverman
Oct 30, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Irene BelmonteFrancisco Rodríguez-Frías
Apr 24, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Simone ScarlataRaffaele Antonelli Incalzi

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