Treponema denticola enolase contributes to the production of antibodies against ENO1 but not to the progression of periodontitis

Virulence
Ahreum LeeYoungnim Choi

Abstract

Autoantibodies against alpha-enolase (ENO1) are often detected in various infectious and autoimmune diseases. Anti-ENO1 antibody titers were reported to be associated with the severity of periodontitis in patients with rheumatoid arthritis. Because the enolase of the periodontal pathogen Treponema denticola (TdEno) has the highest homology with ENO1 among the enolases of human-associated bacteria, we hypothesized that anti-ENO1 autoantibodies produced during the immune response to TdEno may contribute to the progression of periodontitis and tested it in human and mouse systems. In human subjects with healthy periodontium or chronic periodontitis, a strong positive correlation between the levels of anti-TdEno and anti-ENO1 antibodies was observed. In addition, the purified anti-TdEno antibodies recognized ENO1 as well as TdEno in a dot blot, confirming the cross-reactivity between TdEno and ENO1. However, anti-ENO1 antibody titers were not associated with the severity of periodontitis. To further investigate the role of TdEno in the production of anti-ENO1 antibodies and the progression of periodontitis, mice received an oral gavage of P. gingivalis alone, subcutaneous immunization with TdEno alone, or both P. gingivalis oral ga...Continue Reading

References

Apr 28, 2000·Journal of Clinical Periodontology·F MercadoP M Bartold
Jul 17, 2001·Journal of Periodontology·F B MercadoP M Bartold
Aug 11, 2001·Cellular and Molecular Life Sciences : CMLS·V Pancholi
May 9, 2006·Journal of Clinical Periodontology·Lone FornerPalle Holmstrup
Aug 29, 2006·The American Journal of Pathology·Toshihisa KawaiMartin A Taubman
Feb 10, 2007·Autoimmunity Reviews·Benjamin TerrierLuc Mouthon
Jun 7, 2008·Journal of Periodontology·N PischonJ Detert
Feb 16, 2010·Journal of Periodontology·Addie DissickGail S Kerr
Jul 19, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Balkees Taha Garib, Sarhang S Qaradaxi
Jan 26, 2012·Mucosal Immunology·D FarquharsonS Culshaw
May 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seyeon BaeWang Jae Lee
May 2, 2014·Arthritis & Rheumatology·Ted R MikulsJames R O'Dell
Jul 15, 2015·Molecular Oral Microbiology·J-Y LeeB-K Choi
Apr 11, 2017·Nature Reviews. Immunology·David J RawlingsShaun W Jackson
Sep 26, 2017·Journal of Dental Research·K BaekY Choi

❮ Previous
Next ❯

Citations

Feb 26, 2020·Scientific Reports·Soon-Hian TehCheng-Yoong Pang

❮ Previous
Next ❯

Datasets Mentioned

BETA
AAS11440

Methods Mentioned

BETA
ELISA
dot blotting
dot
PCR
dot blot

Software Mentioned

SWISS
Emini
SPSS
SPOT Advanced
GeneDoc
blastp
Emini Surface
MODEL

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.