Treponema denticola stimulates Oncostatin M cytokine release and de novo synthesis in neutrophils and macrophages.

Journal of Leukocyte Biology
Megan M JonesMichelle B Visser

Abstract

Oncostatin M (OSM) is a pleiotropic cytokine elevated in a number of inflammatory conditions including periodontal disease. OSM is produced by a variety of immune cells and has diverse functionality such as regulation of metabolic processes, cell differentiation, and the inflammatory response to bacterial pathogens. The oral cavity is under constant immune surveillance including complementary neutrophil and macrophage populations, due to a persistent symbiotic bacterial presence. Periodontal disease is characterized by a dysbiotic bacterial community, with an abundance of Treponema denticola. Despite strong associations with severe periodontal disease, the source and mechanism of the release of OSM have not been defined in the oral cavity. We show that OSM protein is elevated in the gingival epithelium and immune cell infiltrate during periodontal disease. Furthermore, salivary and oral neutrophil OSM is elevated in correlation with the presence of T. denticola. In an air pouch infection model, T. denticola stimulated higher levels of OSM than the oral pathogen Porphorymonas gingivalis, despite differential recruitment of innate immune cells suggesting T. denticola has distinct properties to elevate OSM levels. OSM release and ...Continue Reading

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Citations

Apr 15, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Malak ZoaiterZaher Zeaiter
May 25, 2021·Journal of Leukocyte Biology·Wenzhe WangBei Li

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