Treprostinil Iontophoresis Improves Digital Blood Flow during Local Cooling in Systemic Sclerosis

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
F Gaillard-BigotJean-Luc Cracowski

Abstract

Severe Raynaud's syndrome and DUs are the most prevalent manifestations of SSc peripheral microvascular disease. We tested whether treprostinil iontophoresis on the finger pad of patients with SSc would improve digital blood flow during hand cooling. Eleven patients with limited cutaneous SSc underwent a double-blinded iontophoresis of treprostinil (2.56 × 10(-4) M during two hours) and placebo (NaCl 0.9%) on two finger pads. Then, the hand was inserted for 30 minutes in a fenestrated cooling box at 8 °C, and skin blood flow was recorded continuously using LSCI. During the local cooling, CVC was significantly higher at the treprostinil site than at the placebo site and remained higher 30 minutes after the test. In patients with SSc, digital treprostinil iontophoresis shifts skin blood flow upward during local cooling of the hand and during the initial rewarming phase. Digital treprostinil iontophoresis should now be tested in larger scale studies.

References

Feb 16, 2007·Clinical Pharmacology and Therapeutics·E A FriedmanD Kurnik
Jan 17, 2009·Annals of the Rheumatic Diseases·O Kowal-BieleckaUNKNOWN EUSTAR Co-Authors
Feb 18, 2009·Annals of the Rheumatic Diseases·L MouthonS Poiraudeau
Jan 26, 2012·Arthritis Care & Research·Andrea FavaFrancesco Boin
Mar 29, 2012·Clinical Pharmacology and Therapeutics·M RoustitJ L Cracowski
Feb 13, 2013·Journal of Clinical Pharmacology·Sophie BlaiseJean-Luc Cracowski
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Dec 24, 2014·Nature Reviews. Rheumatology·Nicholas A Flavahan
Feb 26, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sylvain KotzkiJean-Luc Cracowski
May 23, 2015·Annals of the Rheumatic Diseases·Eric HachullaUNKNOWN SEDUCE study group

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Citations

Feb 23, 2020·Journal of Clinical Pharmacology·Alicia GuiguiJean-Luc Cracowski
Jul 18, 2020·Expert Opinion on Pharmacotherapy·Zsuzsanna H McMahan, Elizabeth R Volkmann
Dec 3, 2020·International Journal of Molecular Sciences·Steffen BrauneFriedrich Jung

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