TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres

Genes & Development
William ChangSusan Smith

Abstract

Mammalian telomeres are coated by the sequence-specific, DNA-binding protein, TRF1, a negative regulator of telomere length. Previous results showed that ADP-ribosylation of TRF1 by tankyrase 1 released TRF1 from telomeres and promoted telomere elongation. We now show that loss of TRF1 from telomeres results in ubiquitination and degradation of TRF1 by the proteasome and that degradation is required to keep TRF1 off telomeres. Ubiquitination of TRF1 is regulated by its telomere-binding status; only the telomere-unbound form of TRF1 is ubiquitinated. Our findings suggest a novel mechanism of sequential post translational modification of TRF1 (ADP-ribosylation and ubiquitination) for regulating access of telomerase to telomeres.

References

Dec 8, 1995·Science·L ChongT de Lange
Feb 20, 1997·Nature·B van Steensel, T de Lange
Nov 5, 1997·Nature Genetics·D BroccoliT de Lange
Nov 5, 1997·Nature Genetics·T BilaudE Gilson
Feb 26, 1998·Cell·B van SteenselT de Lange
Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Nov 20, 1998·Science·S SmithT de Lange
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·C M CounterR A Weinberg
May 25, 1999·Cell·J D GriffithT de Lange
Nov 9, 2000·Current Biology : CB·S Smith, T de Lange
Feb 24, 2001·Genome Biology·E T Kipreos, M Pagano
Mar 14, 2001·Trends in Biochemical Sciences·S Smith
Jul 20, 2001·Experimental Cell Research·L DavidovicG G Poirier
Dec 12, 2001·Molecular and Cellular Biology·Brandoch D CookSusan Smith
Jan 26, 2002·Molecular Biology of the Cell·Satoshi KatayamaTakashi Toda
Feb 19, 2002·Oncogene·Titia de Lange
Mar 30, 2002·Science·Jan KarlsederTitia de Lange

❮ Previous
Next ❯

Citations

Jun 3, 2006·Chromosoma·Nele Hug, Joachim Lingner
Nov 13, 2008·Cytotechnology·Dominique Broccoli
Dec 9, 2003·Trends in Biochemical Sciences·Tomas Simonsson
Jun 21, 2011·Expert Reviews in Molecular Medicine·Tae Ho LeeKun Ping Lu
Aug 3, 2010·Acta Pharmacologica Sinica·Jin-xue HeZe-hong Miao
Jun 30, 2011·Nature Communications·Megan McKerlie, Xu-Dong Zhu
May 11, 2004·Nature Genetics·Jeffrey Zheng-Sheng Ye, Titia de Lange
Jun 21, 2012·Nature Reviews. Molecular Cell Biology·Bryan A Gibson, W Lee Kraus
Nov 22, 2011·Nature Structural & Molecular Biology·Rekha RaiSandy Chang
Jul 3, 2008·The Journal of Biological Chemistry·Brian D Freibaum, Christopher M Counter
Jan 24, 2009·The Journal of Biological Chemistry·Yoon Ra Her, In Kwon Chung
Oct 5, 2007·Nucleic Acids Research·Sascha Beneke, Alexander Bürkle
Oct 7, 2008·Nucleic Acids Research·Sascha BenekeAlexander Bürkle
Jan 12, 2013·Nucleic Acids Research·Yoon Ra Her, In Kwon Chung
Sep 27, 2006·Molecular and Cellular Biology·Qubo ZhuRobert Y L Tsai
Feb 15, 2012·Molecular and Cellular Biology·Tohru YonekawaChristopher M Counter
Nov 9, 2011·Molecular and Cellular Biology·Monica Bhanot, Susan Smith
Oct 29, 2004·Molecular and Cellular Biology·Manu De Rycker, Carolyn M Price
Jul 28, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Marta GladychBlazej Rubis
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Sheila A Stewart, Robert A Weinberg
Aug 6, 2008·Annual Review of Genetics·Wilhelm Palm, Titia de Lange
Oct 15, 2010·BMC Evolutionary Biology·Matteo CitarelliRebecca S Lamb
Oct 3, 2008·Genome Biology·Huawei XinZhou Songyang
Nov 3, 2011·Journal of Cell Science·Lingjun MengRobert Y L Tsai
Jul 30, 2011·PloS One·Marinella G CallowMike Costa
Feb 20, 2014·PloS One·Kara A BoltzDorothy E Shippen
Jun 11, 2014·Nature Reviews. Genetics·Jing YeEric Gilson
Apr 28, 2004·Current Opinion in Genetics & Development·Lea Harrington
Jun 3, 2009·The Journal of Cell Biology·Qubo ZhuRobert Y L Tsai
Feb 18, 2009·The Journal of Cell Biology·Susan J Hsiao, Susan Smith
Apr 30, 2008·The Journal of Cell Biology·Sahn-Ho KimJudith Campisi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.