PMID: 2499400May 8, 1989Paper

TRH analog YM-14673 improves outcome following traumatic brain and spinal cord injury in rats: dose-response studies

Brain Research
A I Faden

Abstract

YM-14673 is a thyrotropin-releasing hormone (TRH) analog that has a modification of the N-terminal (pyroglutamyl) moiety of the tripeptide. It is longer acting than TRH and has substantially greater potency with regard to central facilitatory activity. In the present studies, the effect of YM-14673 was examined in rats following standardized traumatic brain or spinal cord injury. Pentobarbital-anesthetized animals were subjected to fluid-percussion-induced brain trauma to the parietal cortex or impact trauma to the thoracic spinal cord. After injury animals were randomly assigned to treatment with i.v. YM-14673 at varying doses--0.1 mg/kg (low), 1.0 mg/kg (moderate), or 10 mg/kg (high)--or equal volume physiological saline. Treatment with YM-14673 improved chronic neurological recovery after trauma in both injury models; optimal beneficial effects were found at a dose of 1.0 mg/kg. These findings confirm previous observations that TRH or TRH analogs may improve outcome after traumatic brain and spinal cord injury and are consistent with the hypothesis that TRH analogs preserving the C-terminus are effective in CNS trauma.

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Citations

Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S CeylanA Ozoran
Apr 28, 2005·Experimental Brain Research·Memduh KermanNamik Delibas
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Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bogdan StoicaAlan I Faden
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Gregory D Carlson, Carey Gorden
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Oct 5, 2001·Clinical Neuropharmacology·R J DumontA S Dumont
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Aug 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·W Young
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Edward D Hall, Joe E Springer
May 25, 2011·Pharmacology & Therapeutics·Alexander G RabchevskyJoe E Springer
Sep 29, 2012·Journal of Veterinary Emergency and Critical Care·Edward H ParkLisa M Tieber
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Aug 17, 2016·International Journal of Molecular Sciences·Silvia GrottelliIlaria Bellezza
Mar 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alan I FadenAlan P Kozikowski
Mar 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alan I FadenAlan P Kozikowski
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Sep 24, 2005·Annals of the New York Academy of Sciences·Alan I FadenIbolja Cernak
Oct 12, 1999·The American Journal of Physiology·A I FadenA P Kozikowski
Apr 15, 2008·Journal of Natural Products·Anthony R CarrollRonald J Quinn

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