PMID: 2104988Jan 1, 1990Paper

TRH attenuates scopolamine-induced memory impairment in humans

Psychopharmacology
S E MolchanT Sunderland

Abstract

The brain tripeptide thyrotropin-releasing hormone (TRH) has been demonstrated to facilitate cholinergic neurotransmission. To test its interaction with the cholinergic system in humans, high-dose TRH (0.5 mg/kg) or placebo was administered intravenously (IV) to normal controls pretreated with scopolamine (0.5-0.75 mg IV), a centrally active muscarinic antagonist, which has been used to model aspects of the memory impairment of normal aging and of dementia. Compared to placebo, TRH markedly attenuated scopolamine-induced impairment of some measures of memory, most notably on a selective reminding task. This cognitive study is the first in humans to suggest a neuromodulatory effect of a peptide on the cholinergic system, and suggests a facilitatory role for TRH in human memory processes.

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Citations

Sep 9, 2011·Psychopharmacology·Robert A LenzMario D Saltarelli
Sep 29, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jayesh KamathAndrew Winokur
Apr 1, 1995·Pharmacology, Biochemistry, and Behavior·T OgasawaraK Kimura
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Nov 1, 1995·Psychopharmacology·W RiedelJ Jolles
Aug 25, 2011·Integrative Cancer Therapies·Gianluigi MazzoccoliRobert B Sothern
Jan 1, 1994·Journal of Psychopharmacology·C VentraG Schettini
Jan 1, 1993·Journal of Psychopharmacology·H J WeingartnerR G Lister
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Jun 27, 2007·Journal of Psychopharmacology·Christian Gilles, Remy Luthringer
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Jan 9, 2019·Frontiers in Cellular Neuroscience·Cong ZhengXuebing Cao
Oct 25, 2011·Expert Opinion on Therapeutic Patents·Kailas S KhomaneArvind K Bansal

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