Tri-allelic pattern of short tandem repeats identifies the murderer among identical twins and suggests an embryonic mutational origin

Forensic Science International. Genetics
Li-Feng WangYuan-Ming Wu

Abstract

Monozygotic twins can be co-identified by genotyping of short tandem repeats (STRs); however, for distinguishing them, STR genotyping is ineffective, especially in the case of murder. Here, a rarely occurring tri-allelic pattern in the vWA locus (16, 18, 19) was identified only in the DNA of one identical twin, which could help to exonerate the innocent twin in a murder charge. This mutation was defined as primary through genotyping of the family and could be detected in blood, buccal and semen samples from the individual; however, two alternative allele-balanced di-allelic patterns (16, 18 or 16, 19) were detected in hair root sheath cells. Such a kind of segregation indicates a one-step mutation occurs in cell mitosis, which is after embryonic zygote formation and during the early development of the individual after the division of the blastocyte. Sequencing revealed the insertion between the allele 18 and 19 is a repeat unit of TAGA/TCTA (plus/minus strand), which belongs to "AGAT/ATCT"-based core repeats identified from all tri-allelic pattern reports recorded in the STR base and a detailed model was proposed for STR repeat length variation caused by false priming during DNA synthesis. Our model illustrates the possible ori...Continue Reading

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Citations

May 12, 2018·Electrophoresis·Rebecca RichardsSallyAnn Harbison
May 4, 2020·International Journal of Legal Medicine·Sohee ChoSoong Deok Lee
Oct 13, 2019·Forensic Science International. Genetics·Lijuan YuanYuanming Wu
May 26, 2021·Forensic Science International : Synergy·Qinrui YangJianhui Xie

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