Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics

Biophysics Reviews
Brandon J BiesiadeckiPaul M L Janssen

Abstract

Cardiac muscle relaxation is an essential step in the cardiac cycle. Even when the contraction of the heart is normal and forceful, a relaxation phase that is too slow will limit proper filling of the ventricles. Relaxation is too often thought of as a mere passive process that follows contraction. However, many decades of advancements in our understanding of cardiac muscle relaxation have shown it is a highly complex and well-regulated process. In this review, we will discuss three distinct events that can limit the rate of cardiac muscle relaxation: the rate of intracellular calcium decline, the rate of thin-filament de-activation, and the rate of cross-bridge cycling. Each of these processes are directly impacted by a plethora of molecular events. In addition, these three processes interact with each other, further complicating our understanding of relaxation. Each of these processes is continuously modulated by the need to couple bodily oxygen demand to cardiac output by the major cardiac physiological regulators. Length-dependent activation, frequency-dependent activation, and beta-adrenergic regulation all directly and indirectly modulate calcium decline, thin-filament deactivation, and cross-bridge kinetics. We hope to c...Continue Reading

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Citations

Jan 10, 2017·Frontiers in Physiology·Jalal K SiddiquiJonathan P Davis
Aug 7, 2018·Frontiers in Physiology·Jessica L SlabaughPaul M L Janssen
Oct 11, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Nima Milani-NejadPaul M L Janssen
Sep 1, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Charles S ChungSándor J Kovács
Mar 4, 2017·Scientific Reports·Elira MaksutiMartin Ugander
Aug 8, 2018·The Journal of Physiology·Kerry S McDonald
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Feb 26, 2016·Frontiers in Physiology·Ranganath MamidiJulian E Stelzer
Jul 28, 2016·Circulation Research·Paul M L JanssenJonathan P Davis
Dec 27, 2016·Frontiers in Physiology·Hussam E SalhiBrandon J Biesiadecki
Jul 13, 2020·Clinical and Experimental Pharmacology & Physiology·Oleg Lookin
Dec 27, 2016·Frontiers in Physiology·Jae-Hoon ChungPaul M L Janssen
Dec 5, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Martin LaasmaaMarko Vendelin
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May 21, 2021·Heart Failure Reviews·Youn-Hoa JungWei Dong Gao
May 21, 2021·Archives of Biochemistry and Biophysics·Brianna M SchickCharles S Chung

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