Triacylglycerol and wax ester-accumulating machinery in prokaryotes

Biochimie
Héctor M Alvarez

Abstract

Gram negative bacteria as well as Gram positive actinobacteria possess the ability to accumulate variable amounts of wax esters (WE) and/or triacylglycerols (TAG) under nitrogen limiting conditions. In recent years many advances have been made to obtain insight into neutral lipid biosynthesis and accumulation in prokaryotes. The clinical and industrial relevance of bacterial WE/TAG significantly promoted basic and applied research in this field. The recent integrated omic studies as well as the functional characterization of diverse genes are contributing to unravel the composition of the WE/TAG-accumulating machinery in bacteria. This will be a valuable data for designing new drugs against bacteria with clinical importance, such as Mycobacterium tuberculosis, or for transferring and optimizing lipid accumulation in bacterial hosts naturally unable to produce such lipids, such as Escherichia coli. In this article, recent investigations addressing WE/TAG biosynthesis and storage in prokaryotes are presented. A comprehensive view of the current knowledge on the different genes/proteins involved in WE/TAG biosynthesis is included.

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Citations

Jun 27, 2018·Microbial Biotechnology·Alexander BollingerKarl-Erich Jaeger
Jul 31, 2016·Applied and Environmental Microbiology·Annika RöttigAlexander Steinbüchel
Oct 30, 2018·Microbiology·Martín A Hernández, Héctor M Alvarez
Nov 9, 2017·Science Progress·Olga A Nev, Hugo A Van Den Berg
Jul 22, 2019·Applied and Environmental Microbiology·Héctor M AlvarezMaria S Villalba
Nov 11, 2019·Applied and Environmental Microbiology·Johannes HolertWilliam W Mohn
Aug 11, 2020·Plant & Cell Physiology·Jeffrey C Cameron
Sep 13, 2020·Applied Microbiology and Biotechnology·Martina CappellettiDavide Zannoni
Jan 20, 2021·Signal Transduction and Targeted Therapy·Jia-Xi ChenJi-Cheng Li
Feb 24, 2021·Archives of Microbiology·Mariana P LanfranconiHéctor M Alvarez
Apr 30, 2020·Progress in Lipid Research·Peter K LundquistRoberto Espinoza-Corral
Dec 19, 2020·Biotechnology Advances·Laura K MartinIan P Thompson
May 27, 2021·FEMS Microbiology Reviews·Ivy MallickStéphane Canaan
Jun 26, 2021·Scientific Reports·Agostina Crotta AsisGabriela Gago
Aug 16, 2021·Metabolic Engineering·Ya-Hue Valerie SoongDongming Xie
Oct 2, 2021·The ISME Journal·Kyle Mason-JonesWim H van der Putten

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