Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)?

Trials
Shaun TreweekPaula R Williamson

Abstract

Randomised trials are a central component of all evidence-informed health care systems and the evidence coming from them helps to support health care users, health professionals and others to make more informed decisions about treatment. The evidence available to trialists to support decisions on design, conduct and reporting of randomised trials is, however, sparse. Trial Forge is an initiative that aims to increase the evidence base for trial decision-making and in doing so, to improve trial efficiency.One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. This guidance document provides a brief definition of SWATs, an explanation of why they are important and some practical 'top tips' that come from existing experience of doing SWATs. We hope the guidance will be useful to trialists, methodologists, funders, approvals agencies and others in making clear what a SWAT is, as well as what is involved in doing one.

References

Feb 7, 2012·Journal of Clinical Epidemiology·Shaun TreweekFrank Sullivan
Mar 27, 2013·Journal of Evidence-based Medicine
Jan 25, 2014·Trials·Catrin Tudur SmithPaula Williamson

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Citations

Aug 4, 2018·Current Opinion in Critical Care·Theodore J Iwashyna, Joanne McPeake
Sep 1, 2018·Clinical Trials : Journal of the Society for Clinical Trials·Anna KearneyCarrol Gamble
Sep 28, 2018·Clinical Trials : Journal of the Society for Clinical Trials·Miles D WithamVera Cvoro
Nov 16, 2019·Journal of Empirical Research on Human Research Ethics : JERHRE·Megan PrictorHarriet J A Teare
Feb 6, 2020·BMJ : British Medical Journal·Aaron M Drucker, An-Wen Chan
Jan 3, 2020·Clinical Trials : Journal of the Society for Clinical Trials·Janice L RudkowskiJohn R Goffin
Mar 27, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Nabeel SaifRichard S Isaacson
Jun 17, 2020·Journal of Evidence-based Medicine·Marah ElfghiWael Tawfick
Mar 2, 2019·BMC Research Notes·Andrew J CohenBenjamin N Breyer
Sep 23, 2020·Therapeutic Innovation & Regulatory Science·Jennifer LaiKit N Simpson
Feb 6, 2021·Clinical Trials : Journal of the Society for Clinical Trials·Ajar KocharMark B Effron
Mar 18, 2021·F1000Research·Rachel Cunningham-BurleyUNKNOWN SSHeW Study Team
Apr 16, 2021·Trials·Laura RobisonUNKNOWN Australasian Kidney Trials Network
Jun 8, 2021·Contemporary Clinical Trials·David CollisterUNKNOWN ACHIEVE investigators
Jun 18, 2021·BMJ Open·Matthew R SydesUNKNOWN Data Enabled Trials Group Workshop Group members

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