Abstract
The Trial of Antihypertensive Intervention and Management evaluated nine diet-drug combinations in 878 mildly hypertensive, moderately obese participants using a 3 x 3 factorial design. Drugs evaluated were placebo, diuretic (chlorthalidone), and beta-blocker (atenolol); diets were usual (no intervention), weight reduction, and low sodium/high potassium (Na/K). This article reports 6-month dietary changes and the effect of dietary change on blood pressure. Six-month mean weight change was -4.7 kg in the weight reduction group, -0.3 kg in the Na/K group, and -0.5 kg in the usual-diet group. At 6 months, daily electrolyte excretion had changed in the Na/K intervention group. Daily sodium excretion decreased from 138.0 to 112.0 mmol in the Na/K group and increased from 134.1 to 138.4 mmol in the weight reduction group and from 129.1 to 137.0 mmol in the usual-diet group. Daily potassium output increased from 58.7 to 71.4 mmol in the Na/K group, from 57.0 to 60.5 mmol in the weight reduction group, and from 55.3 to 59.1 mmol in the usual diet group. Analysis of 3-day food records indicated that sodium intake decreased from 141.1 to 85.8 mmol and potassium intake increased from 76.4 to 90.5 mmol. Our results indicate that the goal f...Continue Reading
Citations
Jul 5, 2007·Obesity Surgery·Atul K MadanDavid S Tichansky
Nov 26, 2003·Preventive Medicine·Kim M GansThomas M Lasater
May 27, 2005·Preventive Medicine·Shiriki K KumanyikaMarjorie A Bowman
Feb 16, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K HongD Heber
Jan 1, 2014·The International Journal of Behavioral Nutrition and Physical Activity·Patricia Markham RisicaThomas M Lasater
Jan 5, 2002·Diabetes Care·Marion J FranzMadelyn Wheeler
Jan 1, 1994·Journal of the American Dietetic Association·J Wylie-RosettS Wassertheil-Smoller
May 1, 1994·Journal of the American Dietetic Association·S A SowinskiM H Wagner
Nov 25, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·W S Carlos PostonJ P Foreyt
May 2, 2001·The Cochrane Database of Systematic Reviews·R L ThompsonS Ebrahim
May 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T Kawada
Mar 5, 2016·The Cochrane Database of Systematic Reviews·Thomas SemlitschAndrea Siebenhofer
Aug 8, 2015·The Cochrane Database of Systematic Reviews·Lee HooperC Murray Skeaff
Jun 13, 2015·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
Sep 17, 2004·Journal of Human Hypertension·S K KumanyikaUNKNOWN Trials of Hypertension Prevention Collaborative Research Group
Feb 12, 2002·Obesity Research·Shiriki K KumanyikaUNKNOWN TONE Cooperative Research Group
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Cynthia D MulrowM Brand
Jul 21, 2006·The Cochrane Database of Systematic Reviews·H O DickinsonJ Mason
May 18, 2012·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
Mar 1, 1994·Obesity Research·S K Kumanyika
Mar 7, 2000·Journal of Hypertension·E J BalkesteinL M Van Bortel
Feb 20, 2004·The Cochrane Database of Systematic Reviews·L HooperS Ebrahim
May 20, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Jun 2, 2020·The Cochrane Database of Systematic Reviews·Lee HooperC Murray Skeaff
Aug 23, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Jan 1, 1995·Blood Pressure·P Omvik, O L Myking
Aug 15, 2003·The Cochrane Database of Systematic Reviews·R L ThompsonS Ebrahim
Aug 2, 2000·The American Journal of Clinical Nutrition·M H KorhonenM I Uusitupa
Feb 9, 2021·The Cochrane Database of Systematic Reviews·Thomas SemlitschAndrea Siebenhofer