PMID: 2649308Mar 1, 1989Paper

Trial of antihypertensive interventions and management. Design, methods, and selected baseline results

Controlled Clinical Trials
B R DavisN Zimbaldi

Abstract

The Trial of Antihypertensive Interventions and Management was a multicenter randomized, placebo-controlled trial designed to assess the effectiveness of various combinations of pharmacologic and dietary interventions in the treatment of mild hypertension (diastolic blood pressure 90-100 mmHg). The primary outcome was blood pressure change between baseline and 6 months. The study consisted of a 3 X 3 factorial design wherein participants were randomly allocated to nine drug-diet treatment groups. Drugs included placebo, diuretic, and beta-blocker. Diets were usual, weight loss, and low sodium/high potassium. The basic strategy was to address clinical questions of interest by comparing mean blood pressure changes of selected drug-diet combinations. This paper describes the study including experimental design, sample size considerations, statistical analysis, organizational structure, and baseline findings.

Associated Clinical Trials

References

Jun 26, 1986·The New England Journal of Medicine·S H CroogG H Williams
Mar 20, 1987·JAMA : the Journal of the American Medical Association·R StamlerJ Civinelli
Feb 24, 1983·The American Journal of Cardiology·N M Kaplan
Nov 1, 1980·The American Journal of Medicine·A Helgeland

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Citations

Jul 15, 2004·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·A AvenellW C S Smith
Mar 21, 1998·Journal of the American Dietetic Association·M SelfJ Brancato
Dec 10, 1990·American Journal of Health Promotion : AJHP·S A CorriganS G Jennings
Mar 5, 2016·The Cochrane Database of Systematic Reviews·Thomas SemlitschAndrea Siebenhofer
Aug 8, 2015·The Cochrane Database of Systematic Reviews·Lee HooperC Murray Skeaff
Jun 13, 2015·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
Mar 31, 2016·Internal and Emergency Medicine·Lizzy M BrewsterYackoob K Seedat
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Cynthia D MulrowM Brand
May 18, 2012·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
May 20, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Jun 2, 2020·The Cochrane Database of Systematic Reviews·Lee HooperC Murray Skeaff
Aug 23, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Jan 1, 1995·American Journal of Human Biology : the Official Journal of the Human Biology Council·Sylvia Wassertheil-SmollerKent Kirchner
Feb 9, 2021·The Cochrane Database of Systematic Reviews·Thomas SemlitschAndrea Siebenhofer
Feb 13, 2001·The Journal of Nutrition·C M LoriaN D Ernst

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