PMID: 4396185Mar 20, 1971

Trial of new bronchodilator, terbutaline, in asthma

British Medical Journal
B J Freedman

Abstract

Terbutaline, a new bronchodilator acting on beta-adrenergic receptors, was given to 10 asthmatic patients, who received on separate days 5 mg orally, 10 mg orally, and 0.25 mg subcutaneously. The ventilatory response was assessed by measurement of the FEV(1) before and at intervals after administration. The cardiovascular response was assessed by measurement of the heart rate and blood pressure and by electrocardiography at the same times as spirometry was performed.The ventilatory response to all three doses and by both routes was satisfactory. The maximal increase in FEV(1) after 5 mg orally was only slightly less than that after 10 mg. The maximal increase in heart rate after 5 mg orally was about half that which occurred after 10 mg. It is concluded that 5 mg orally and 0.25 mg subcutaneously are suitable doses.In general a modest fall in blood pressure affected the diastolic more than the systolic. On E.C.G. the T wave was often depressed, and in one patient, it was inverted. A trough-like depression of the QRS baseline occurred several times. The significance of the E.C.G. changes is uncertain.

References

Sep 15, 1969·Experientia·J BergmanK Wetterlin
Jan 1, 1970·British Journal of Diseases of the Chest·W D RidingS S Chatterjee

Citations

Jan 1, 1974·European Journal of Clinical Pharmacology·S Johansen
Jan 1, 1971·European Journal of Pharmacology·R H Burnell, G M Maxwell
Jul 1, 1978·JACEP·R C Bone, C Hiller
Apr 1, 1974·British Journal of Clinical Pharmacology·D S DaviesC T Dollery
Jun 1, 1974·British Journal of Clinical Pharmacology·J M Watson, A Richens
Mar 1, 1973·Archives of Disease in Childhood·J Leegaard, S Fjulsrud
Mar 1, 1973·Thorax·G M Shenfield, J W Paterson
Dec 1, 1975·Australian and New Zealand Journal of Medicine·S D AndersonD A Lindsay
Dec 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·W D ConwayR N Boyes
Jan 1, 1973·Current Medical Research and Opinion·G M CochraneM E Hanan
Jan 3, 2012·Pulmonary Pharmacology & Therapeutics·Mario Cazzola, Maria Gabriella Matera
Aug 1, 1978·The Journal of Pediatrics·B ArdalA H Eisen
Jul 1, 1973·British Journal of Diseases of the Chest·J GaddieK N Palmer
Oct 1, 1977·Chest·L M PangR B Mellins
Apr 1, 1979·The Journal of Social Psychology·S Stack
Sep 1, 1972·Acta Allergologica·D J KanarekS Zwi
Apr 1, 1976·The Journal of Pharmacy and Pharmacology·W C Bowman, C Raper

Related Concepts

Adrenergic beta-Agonists
Amino Alcohols
Asthma
Diastolic Blood Pressure
Broncholytic Effect
Butylamines
Electrocardiographic Recorders
Pulse Rate
Resorcinols
Spirometry

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