Trial of preventing hypertension: design and 2-year progress report

Hypertension
Stevo JuliusTROPHY study group

Abstract

The TRial Of Preventing HYpertension (TROPHY) study is an investigator-initiated trial to examine whether early pharmacological treatment in subjects with "high-normal" blood pressure (BP) might prevent or delay the development of clinical hypertension. This is a 4-year, multicenter, randomized, double-blind study in untreated subjects aged 30 to 65 years with entry BPs of 130 to 139/< or =89 or < or =139/85 to 89. The participants were randomized either to placebo or to a fixed (16 mg once daily) dose of candesartan cilexetil (candesartan). After 2 years, the candesartan group was switched to placebo, and the placebo group continued taking placebo. The main outcome measure was the development of clinical (treatment-requiring) hypertension assessed by an automated (blinded) BP measurement device. We randomized 809 subjects (59% males, average age 49.0+/-SD 8.1 years) in 71 study centers in the United States. The entry BP was 134+/-4.3/84.8+/-3.9 mm Hg. During the first 2 years, 187 subjects (23%) developed clinical hypertension. All have been given antihypertensive treatment, and 170 continue to be followed in study centers. The study dropout rate is 14.8% (120 subjects). The hypertension rates are higher than anticipated, wher...Continue Reading

Associated Clinical Trials

References

Feb 1, 1985·JAMA : the Journal of the American Medical Association·H G LangfordJ D Abernethy
Mar 1, 1971·Journal of Chronic Diseases·S Julius, M A Schork
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·J F GiudicelliC Richer
Feb 1, 1994·Clinical and Experimental Pharmacology & Physiology·S B HarrapA F Lever
Jan 17, 2002·The New England Journal of Medicine·R S VasanD Levy
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Mar 29, 2003·Diabetes Care·UNKNOWN Diabetes Prevention Program Research Group

❮ Previous
Next ❯

Citations

Sep 15, 2005·Current Hypertension Reports·Norman M Kaplan
May 24, 2007·Current Hypertension Reports·Stevo Julius
Mar 26, 2010·Journal of Human Hypertension·O J MacEneaneyB L Stauffer
Mar 29, 2013·Journal of Human Hypertension·E B LevitanP Muntner
Mar 16, 2006·The New England Journal of Medicine·Stevo JuliusUNKNOWN Trial of Preventing Hypertension (TROPHY) Study Investigators
Apr 11, 2007·Current Opinion in Nephrology and Hypertension·Shawna D Nesbitt
Dec 23, 2011·Oxidative Medicine and Cellular Longevity·Rebecca M KappusScott R Collier
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Dimitris P PapadopoulosVasilios Papademetriou
Jun 16, 2005·Current Opinion in Cardiology·Edward D Frohlich
Mar 2, 2006·Journal of Hypertension·Norman M Kaplan
Oct 21, 2006·Journal of Hypertension·Carmel M McEnieryJohn R Cockcroft
Jul 26, 2006·Blood Pressure·Sverre E KjeldsenThomas Hedner
Oct 16, 2007·Blood Pressure·P A Van Zwieten
Jan 1, 2008·Journal of the American Society of Hypertension : JASH·Stevo JuliusUNKNOWN Trial of Preventing Hypertension (TROPHY) Investigators
Oct 18, 2005·The Journal of Clinical Hypertension·Thomas D GilesMichael A Weber
Aug 8, 2007·Journal of the Cardiometabolic Syndrome·Shawna D Nesbitt
Dec 17, 2008·Statistics in Medicine·Niko A KacirotiStevo Julius
Aug 19, 2008·The Journal of Clinical Hypertension·Mark C Houston, Karen J Harper
Jan 17, 2012·Journal of the American Academy of Nurse Practitioners·Johnanna Hernandez, Stoerm Anderson
Oct 4, 2013·The Journal of Clinical Hypertension·Jay I Meltzer
Nov 27, 2009·Postgraduate Medicine·Shawna D Nesbitt
Jul 19, 2008·Journal of the American College of Cardiology·Chi Young ShimNamsik Chung
Dec 20, 2007·American Journal of Hypertension·Thomas LumleyBruce M Psaty
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Brent M EganStevo Julius
Jul 13, 2005·Hypertension·Norman M Kaplan
Nov 19, 2010·American Journal of Physiology. Renal Physiology·Sharon S LandgrafCelso Caruso-Neves
May 11, 2021·Journal of Hypertension·Tiny Nair, C Venkata S Ram

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.