Trial of tramadol plus gabapentin for opioid detoxification

Iranian Red Crescent Medical Journal
Hassan ZiaaddiniMahin Eslami

Abstract

Substance abuse or drug addiction is one of the most important health issues in every society, which can lead to physical and mental problems. This study aimed to compare the efficacy of tramadol plus gabapentin versus methadone use in the treatment of opiate withdrawal. Consenting male subjects who fulfilled the DSM-4 criteria for opiate dependence syndrome (opium, residue, and heroin) were randomly assigned in two groups to receive tramadol plus gabapentin or methadone. Assessment tools were Adjective Rating Scale for Withdrawal (ARSW), Clinical Opiate Withdrawal Scale (COWS) and Visual Analogue craving Scale (VAS). Fifty-nine subjects were enrolled and evaluated on days 1, 2, 3, 4, 6, and 8 during their 10 days of admission. Twenty-nine participants received methadone and the other 30 received tramadol plus gabapentin for their treatment. Mean (SD) age of the patients in methadone group and tramadol plus gabapentin group were 33.9 (7.1) and 32.4. (8.1), respectively (P = 0.462). The overall ARSW (P value = 0.263) and COWS (P = 0.862) scores between the two groups were comparable. The differences in the VAS score for craving between the two groups was marginally significant (P = 0.057). The highest VAS score was at the third ...Continue Reading

References

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Jun 23, 2009·Annals of Emergency Medicine·Amy S B BohnertSandro Galea
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May 1, 2012·Journal of Addictive Diseases·Mehran ZarghamiMohammad-Reza Shiran
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May 28, 2013·Journal of Opioid Management·Jatinder Mohan ChawlaYatan Pal Singh Balhara
Jul 17, 2013·Experimental and Clinical Psychopharmacology·Nichole C SandersAlison H Oliveto

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