Trials and projects on cervical cancer and human papillomavirus prevention in sub-Saharan Africa

Vaccine
Peter O AdefuyeLynette A Denny

Abstract

Cervical cancer is the leading cause of cancer morbidity and mortality in women in sub-Saharan Africa (SSA), accounting for about 50,000 deaths annually. Until recently, cytology was the gold standard for screening and prevention of cervical cancer. This method of screening has not been successful in SSA due to a lack of human, financial and material resources and poor health care infrastructure. It is estimated that less than 5% of at risk women have ever being screened. In the past two decades alternative approaches to cytology for cervical cancer screening have been evaluated in low- and medium-income countries. Visual inspection with acetic acid (VIA) and/or Lugol's iodine (VILI) have been shown to have adequate sensitivity, although low specificity, in a number of cross-sectional research and demonstration projects. Visual inspection methods require minimal resources, are technologically accessible, and are feasible for screening for precancerous lesions. Linking screening with VIA/VILI to treatment with cryotherapy may enable screening and treatment to take place in one visit, but this is likely to result in large numbers of women being subjected to unnecessary treatment. A number of studies have shown that cryotherapy is...Continue Reading

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Citations

Aug 6, 2014·Archives of Virology·Yumei WangShangxian Gao
Dec 18, 2013·Vaccine·Lynette A DennyF Xavier Bosch
Feb 11, 2018·Implementation Science : IS·Lauren G JohnsonAlison M Buttenheim
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