Triamcinolone acetonide and hexacetonide intra-articular treatment of symmetrical joints in juvenile idiopathic arthritis: a double-blind trial

Rheumatology
Francesco ZulianP Manners

Abstract

Pharmacokinetic studies have shown that the biological effect of triamcinolone acetonide (TA) is equivalent to that of triamcinolone hexacetonide (TH), if used at double the dosage. In this study we compared the efficacy of intra-articular TA at a dose twice that of TH in symmetrically involved joints, in children with juvenile idiopathic arthritis (JIA). Children with active arthritis and a similar degree of inflammation in two symmetrical joints were enrolled in the study. The symmetry was assessed by both clinical examination and synovial fluid analysis. The dose given was 1 mg/kg up to 40 mg of TH or 2.0 mg/kg up to 80 mg of TA. The identity of injected compound was blinded to the patient and to the physician. Thirty-seven patients, 30 female, seven male, with JIA, entered the study. A total of 86 joints were injected. Twenty-one (53.8%) of the joints injected with TA relapsed first compared with only six (15.4%) of the joints injected with TH. In three (7.7%) relapse occurred simultaneously. Nine (23%) were still in remission after 24-month follow-up. The percentage of joints with lasting remission was higher with TH than with TA (80 vs 47.5% after 12 months and 63.6 vs 32.4% after 24 months, respectively; log rank test P ...Continue Reading

Citations

Mar 27, 2013·Pediatric Radiology·Mahesh ThapaWilliam E Shiels
Aug 28, 2010·Zeitschrift für Rheumatologie·G Horneff
Mar 3, 2009·Clinical Rheumatology·George S Habib
Apr 23, 2013·Current Allergy and Asthma Reports·Julia G HarrisJames W Verbsky
Nov 10, 2006·Current Rheumatology Reports·Philip J Hashkes, Ronald M Laxer
Apr 24, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·P MolhoY Sultan
Mar 22, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Muhammad M Abd-El-BarrEric R Holz
Jun 2, 2006·Journal of Paediatrics and Child Health·Rubina Hameed, Margaret R Zacharin
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Natasha M Ruth, Murray H Passo
Jan 17, 2013·Pediatric Rheumatology Online Journal·Boris HugleSusanne M Benseler
Jul 2, 2009·Paediatric Drugs·Srilakshmi M SharmaAthimalaipet V Ramanan
Jan 7, 2014·Rheumatology International·S NimmrichG Horneff
May 2, 2014·Pediatric Rheumatology Online Journal·Matthew L Stoll, Randy Q Cron
May 16, 2014·Inflammopharmacology·Justin SchererWalter F Kean
Dec 17, 2005·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Esi M DeWittRandy Q Cron
Aug 27, 2011·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·George S Habib, Walid Miari
Sep 29, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Bernardo Gialanella, Paola Prometti
Mar 27, 2013·Expert Opinion on Pharmacotherapy·Dawn M Wahezi, Norman T Ilowite
Mar 1, 2006·Expert Opinion on Pharmacotherapy·Giorgia Martini, Francesco Zulian
Dec 4, 2009·Expert Opinion on Pharmacotherapy·Ariane Klein, Gerd Horneff
Mar 1, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·S El Assar de la FuenteK Rosendahl
Mar 14, 2016·Revista brasileira de reumatologia·Ana Luiza Garcia CunhaMaria Teresa de Sande E Lemos Ramos Ascensão Terreri
Nov 5, 2013·Rheumatic Diseases Clinics of North America·Matthew L Stoll, Randy Q Cron
Jul 24, 2012·Rheumatic Diseases Clinics of North America·Katherine Anne B Marzan, Bracha Shaham
May 9, 2012·Pediatric Clinics of North America·Peter J Gowdie, Shirley M L Tse
Nov 9, 2010·Techniques in Vascular and Interventional Radiology·Jack-Nghia VoDennis W W Shaw
Oct 16, 2007·Rheumatic Diseases Clinics of North America·Jennifer E Weiss, Norman T Ilowite
Nov 1, 2008·Arthritis and Rheumatism·Timothy BeukelmanDaniel A Albert
Oct 18, 2013·Geriatrics & Gerontology International·Bernardo Gialanella, Maurizio Bertolinelli
May 8, 2013·Journal of Paediatrics and Child Health·Genevieve Tyra Ostring, Davinder Singh-Grewal
Apr 18, 2014·Annals of the New York Academy of Sciences·Clara Malattia, Alberto Martini
Apr 12, 2005·Pediatric Clinics of North America·Jennifer E Weiss, Norman T Ilowite
Jul 6, 2014·Rheumatology·Elizabeth J CoulsonHelen E Foster
Dec 14, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Gregor DueckersTim Niehues
Aug 4, 2016·Paediatric Drugs·Štefan BlazinaTadej Avčin
May 25, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Olivia T ChengJianguo Cheng

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