Triamidetriamine bearing macrobicyclic and macrotricyclic ligands: potential applications in the development of copper-64 radiopharmaceuticals

Inorganic Chemistry
Kel Vin TanPeter J Barnard

Abstract

A versatile and straightforward synthetic approach is described for the preparation of triamide bearing analogues of sarcophagine hexaazamacrobicyclic cage ligands without the need for a templating metal ion. Reaction of 1,1,1-tris(aminoethyl)ethane (tame) with 3 equiv of 2-chloroacetyl chloride, yields the tris(α-chloroamide) synthetic intermediate 6, which when treated with either 1,1,1-tris(aminoethyl)ethane or 1,4,7-triazacyclononane furnished two novel triamidetriamine cryptand ligands (7 and 8 respectively). The Co(III) and Cu(II) complexes of cryptand 7 were prepared; however, cryptand 8 could not be metalated. The cryptands and the Co(III) complex 9 have been characterized by elemental analysis, (1)H and (13)C NMR spectroscopy, and X-ray crystallography. These studies confirm that the Co(III) complex 9 adopts an octahedral geometry with three facial deprotonated amido-donors and three facial amine donor groups. The Cu(II) complex 10 was characterized by elemental analysis, single crystal X-ray crystallography, cyclic voltammetry, and UV-visible absorption spectroscopy. In contrast to the Co(III) complex (9), the Cu(II) center adopts a square planar coordination geometry, with two amine and two deprotonated amido donor g...Continue Reading

References

Jun 23, 1976·Journal of the American Chemical Society·F P Bossu, D W Margerum
Nov 12, 1975·Journal of the American Chemical Society·D W MargerumG L Bruce
Jan 1, 1993·Clinical Nuclear Medicine·J P O'MalleyN Chantarapitak
Aug 12, 2000·Nuclear Medicine and Biology·C S CutlerM J Welch
Nov 4, 2004·Journal of Inorganic Biochemistry·Suzanne V Smith
Oct 13, 2006·Organic & Biomolecular Chemistry·Nadine Di BartoloSuzanne V Smith
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Stephan D VossAlan B Packard
Dec 25, 2007·Acta Crystallographica. Section A, Foundations of Crystallography·George M Sheldrick
Mar 17, 2009·Physics in Medicine and Biology·Jason P HollandJonathan R Dilworth
Jun 18, 2009·Accounts of Chemical Research·Monica Shokeen, Carolyn J Anderson
Jul 1, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Hancheng CaiPeter S Conti
Aug 22, 2009·Cancer Biotherapy & Radiopharmaceuticals·Carolyn J Anderson, Riccardo Ferdani
Jan 5, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Paul S Donnelly

❮ Previous
Next ❯

Citations

Oct 4, 2014·Inorganic Chemistry·Chung Ying ChanPeter J Barnard
May 11, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Caterina F RamogidaChris Orvig
May 10, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Mayank GuptaParimal K Bharadwaj
Jun 7, 2014·Inorganic Chemistry·Peter CombaKristof Zarschler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.