PMID: 1100300Sep 11, 1975Paper

Triazolam in insomniac family practice patients

Clinical Pharmacology and Therapeutics
K RickelsA Schilling


Triazolam, 0.5 mg, a benzodiazepine with hypnotic properties, was compared to secobarbital, 100 mg, and placebo in a 1-wk study conducted with 100 insomniac family practice patients. Considerable sensitivity to differential treatment effects was demonstrated for these family practice patients as well as for a research methodology that combines a crossover design, permitting preference ratings, with a between-patient design. In almost all sleep parameters, assessed with a variety of subjective techniques, triazolam and secobarbital were shown to be significantly more effective than placebo. Triazolam was consistently and often significantly indicated to be a more effective hypnotic, particularly for reducing nocturnal awakening, than secobarbital. Analysis of self-report emotional distress data revealed that present insomniac patients were slightly more emotionally symptomatic than other nonpsychiatric populations. Triazolam was followed by the greatest and secobarbital the least relief of emotional symptoms and triazolam emerged as an especially effective hypnotic for initially more depressed insomniac patients. Present findings suggest that type and degree of emotional symptomatology may affect the response of insomniac patien...Continue Reading


Jan 1, 1980·The Journal of International Medical Research·V PegramP Linton
Jan 1, 1981·British Journal of Clinical Pharmacology·R I Shader
May 1, 1983·Journal of Clinical Pharmacology·K RickelsR Weinstock
Jun 15, 1978·Psychopharmacology·K Rickels
Jan 1, 1981·British Journal of Clinical Pharmacology·R P Purpura
Jan 1, 1978·The Journal of International Medical Research·A J Bowen
Jan 1, 1976·The Journal of International Medical Research·P Lomen, O I Linet
Jan 1, 1978·The Journal of International Medical Research·K K Okawa, G S Allens
Jan 1, 1980·Psychopharmacology·C OguraW M Wardell
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·K Rickels

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