PMID: 3752434Jul 1, 1986Paper

Triazolam premedication. A comparison with lorazepam and placebo in gynaecological patients

Anaesthesia
D ThomasM A Hollands

Abstract

A randomised, double blind study, of 58 female patients undergoing laparoscopic investigation was carried out to compare triazolam 0.25 mg, lorazepam 2 mg, or placebo as oral premedication. Each patient was assessed by only one of the authors both pre- and postoperatively with regard to anxiolysis, sedation and rapidity of recovery. Triazolam and lorazepam were each associated with a significant reduction in anxiety compared to the initial assessment, whereas placebo had no anxiolytic effect. Sixty minutes after premedication, patients who had received triazolam were significantly more sleepy than patients given placebo or lorazepam. Two hours after the operation, the patients who had had triazolam or lorazepam were significantly more sleepy than those who received placebo. However, at 6 hours postoperatively there was no difference between triazolam and placebo, whilst those who had been given lorazepam were still significantly more sleepy than those given placebo. Triazolam appears to offer advantages over either lorazepam or placebo in patients who require rapid recovery, sedation and reduction in pre-operative anxiety.

References

Jan 1, 1976·The Journal of International Medical Research·L F FabreR T Harris
Jan 1, 1979·Journal of Pharmaceutical Sciences·D J GreenblattE Woo
Jan 1, 1977·British Medical Journal·C M CastledenC Hallett
Jun 1, 1977·British Journal of Anaesthesia·W WassenaarG D Gale
Oct 15, 1977·British Medical Journal·J M LeighP Janaganathan
Oct 1, 1972·Anaesthesia·M A Ramsay
Oct 1, 1969·British Journal of Anaesthesia·J WilsonD B Scott
Jun 1, 1967·British Journal of Anaesthesia·W Norris, W L Baird
Sep 27, 1980·British Medical Journal·M R KeighleyR J Gammon
Sep 1, 1980·British Journal of Clinical Pharmacology·I Hindmarch
Oct 1, 1960·Journal of Consulting Psychology·M ZUCKERMAN

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Citations

Oct 13, 2009·The Cochrane Database of Systematic Reviews·Kevin J Walker, Andrew F Smith
Oct 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H J PenttiläA M Partanen
Jan 1, 1990·European Journal of Clinical Pharmacology·R AantaaT Nyrke

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