Triazole-Directed Pd-Catalyzed C(sp(2))-H Oxygenation of Arenes and Alkenes

Organic Letters
Aitziber IrastorzaArkaitz Correa

Abstract

Selective Pd-catalyzed C(sp(2))-H oxygenation of 4-substituted 1,2,3-triazoles is described. Unlike previous metal-catalyzed C-H functionalization events, which preferentially occur at the activated heterocyclic C-H bond, the regioselective oxygenation of the arene/alkene moiety is now achieved featuring the unconventional role of a simple triazole scaffold as a modular and selective directing group.

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Citations

Aug 31, 2016·Topics in Current Chemistry·Gianpiero Cera, Lutz Ackermann
Feb 10, 2017·Organic Letters·Asier GoitiaArkaitz Correa
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Aug 23, 2019·Chemistry : a European Journal·Matteo VirelliLutz Ackermann
Jan 27, 2018·Chemical Communications : Chem Comm·Itziar GuerreroArkaitz Correa

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