Triazoles: a valuable insight into recent developments and biological activities

Chinese Journal of Natural Medicines
Jagdish K SahuAtul Kaushik

Abstract

In recent years, heterocyclic compounds, analogs, and derivatives have attracted strong interest due to their useful biological and pharmacological properties. The small and simple triazole nucleus is present in compounds aimed at evaluating new entities that possess anti-microbial, anti-tumor, antitubercular, anti-convulsant, anti-depressant, antimalarial, and anti-inflammatory activities. Triazoles display a broad range of biological activities and are found in many potent, biologically active compounds, such as trazodone (antidepressant drug), rizatriptan (antimigrane drug), hexaconazole (antifungal drug) and alprazolam (hyptonic, sedative and tranquilizer drug). So far, modifications of the triazole ring have proven highly effective with improved potency and lesser toxicity. The present review highlights the recently synthesized triazoles possessing important biological activities.

Citations

Jan 31, 2016·European Journal of Medicinal Chemistry·Adile AyatiAlireza Foroumadi
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Sep 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kranthi Kumar GanguSreekantha B Jonnalagadda
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