Triazolophanes: a new class of halide-selective ionophores for potentiometric sensors

Analytical Chemistry
Elsayed M ZahranLeonidas G Bachas


Triazolophanes, cyclic compounds containing 1,2,3-triazole units, are a new class of host molecules that demonstrate strong interactions with halides. These molecules are designed with a preorganized cavity that interacts through hydrogen bonding with spherical anions, such as chloride and bromide. We have explored the use of one such triazolophane as a halide-selective ionophore in poly(vinyl chloride) (PVC) membrane electrodes. Different membrane compositions were evaluated to identify concentrations of the ionophore, plasticizer, and lipophilic additive that give rise to the best chloride and bromide selectivity. The lipophilicity of the plasticizer was found to have a great impact on the electrode response. Additionally, the concentration of the lipophilic additive was found to be critical for optimal response. The utility of a triazolophane-based electrode was demonstrated by quantification of bromide in horse serum samples.


Mar 8, 2011·Chemical Society Reviews·Yu Heng LauMatthew H Todd
Dec 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Albert C FahrenbachJ Fraser Stoddart
Nov 5, 2014·The Analyst·Miriam Más-MontoyaAlberto Tárraga
Jun 29, 2011·Chemistry : a European Journal·Raghunath O RamabhadranKrishnan Raghavachari
Sep 3, 2011·Chemistry, an Asian Journal·Albert C Fahrenbach, J Fraser Stoddart
Aug 3, 2010·Organic & Biomolecular Chemistry·Masafumi YanoPhilip A Gale
Feb 5, 2014·Chemical Society Reviews·Benjamin Schulze, Ulrich S Schubert
Jan 19, 2012·Chemical Communications : Chem Comm·Kevin P McDonaldAmar H Flood
Dec 20, 2013·The Analyst·Elsayed M ZahranLeonidas G Bachas
Nov 15, 2011·Chemical Society Reviews·Marco WenzelPhilip A Gale

Related Concepts

poly(vinyl chloride)-poly(vinyl acetate) copolymer
Spherical Shape
Chloride Ion
Cyclic compound
Specimen Type - Serum

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.