Tribute to Paul Janssen (1926-2003): two discoveries per year"

Annales pharmaceutiques françaises
Fr Chast

Abstract

Paul Janssen (1926-2003) performed during fifty Years an intense pharmaceutical research activity. From 1953 to 2003, he discovered numerous new drugs in various fields of pharmacology. He widened the neuroleptic spectrum with haloperidol and risperidone, the opioid one with dextromoramide, fentanyl and its short-life derivates, constipating agents like loperamide, hypnotics, anaesthetics. In the field of anti-infectious agents, he discovered azole antifungals, parasiticides among which levamisole and mebendazole. Other therapeutic classes have been enriched by JANSSEN's works: vasodilatating agents, antihypertensive and anti-allergic drugs, etc. More recently, his research was oriented towards virology namely anti-HIV drugs. When Paul JANSSEN's life ended, his scientific production seemed to be one of the most eminent in the XXth century.

References

Apr 1, 1992·Antimicrobial Agents and Chemotherapy·F G HaydenP A Janssen
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Van GinckelP A Janssen
Jun 8, 1990·European Journal of Pharmacology·R XhonneuxP A Janssen
Apr 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M D KrekelsP A Janssen
May 1, 1991·Journal of Clinical Pharmacology·P A Janssen
Jan 1, 1990·Pharmacopsychiatry·F AwoutersP A Janssen
Apr 1, 1989·Antimicrobial Agents and Chemotherapy·W al-NakibP A Janssen
Oct 1, 1989·Journal of Medicinal Chemistry·J P Van Wauwe, P A Janssen
Oct 26, 1988·European Journal of Pharmacology·A Van de WaterP A Janssen
Jul 15, 1970·European Journal of Pharmacology·P A JanssenW K Schaper
Mar 12, 1966·Nature·D ThienpontP A Janssen
Jul 1, 1966·Journal of Medicinal Chemistry·A H RaeymaekersP A Janssen
Nov 1, 1967·Journal of Medicinal Chemistry·E F GodefroiP A Janssen
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·J Van CutsemP A Janssen
Feb 1, 1995·Antimicrobial Agents and Chemotherapy·F G HaydenK Andries
Aug 31, 2001·Bioorganic & Medicinal Chemistry Letters·D W LudoviciP A Janssen
Aug 31, 2001·Bioorganic & Medicinal Chemistry Letters·D W LudoviciP A Janssen
Aug 31, 2001·Bioorganic & Medicinal Chemistry Letters·D W LudoviciP A Janssen
Jun 13, 2003·Journal of Medicinal Chemistry·H Maarten VinkersPaul A J Janssen
Sep 1, 1961·The Journal of Pharmacy and Pharmacology·P A JANSSEN
Aug 1, 1959·Journal of Medicinal and Pharmaceutical Chemistry·P A JANSSENJ HUYGENS
Jan 10, 2004·Journal of Computer-aided Molecular Design·H M VinkersP A J Janssen

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