Tributyltin and triphenyltin exposure promotes in vitro adipogenic differentiation but alters the adipocyte phenotype in rainbow trout

Aquatic Toxicology
Esmail LutfiI Navarro

Abstract

Numerous environmental pollutants have been identified as potential obesogenic compounds affecting endocrine signaling and lipid homeostasis. Among them, well-known organotins such as tributyltin (TBT) and triphenyltin (TPT), can be found in significant concentrations in aquatic environments. The aim of the present study was to investigate in vitro the effects of TBT and TPT on the development and lipid metabolism of rainbow trout (Onchorynchus mykiss) primary cultured adipocytes. Results showed that TBT and TPT induced lipid accumulation and slightly enhanced peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer binding protein alpha (C/EBPα) protein expression when compared to a control, both in the presence or absence of lipid mixture. However, the effects were higher when combined with lipid, and in the absence of it, the organotins did not cause complete mature adipocyte morphology. Regarding gene expression analyses, exposure to TBT and TPT caused an increase in fatty acid synthase (fasn) mRNA levels confirming the pro-adipogenic properties of these compounds. In addition, when added together with lipid, TBT and TPT significantly increased cebpa, tumor necrosis factor alpha (tnfa) and ATP-binding cas...Continue Reading

Citations

Mar 4, 2020·International Journal of Molecular Sciences·Natàlia Riera-HerediaIsabel Navarro
Nov 24, 2018·Frontiers in Endocrinology·Francesca Maradonna, Oliana Carnevali
Aug 23, 2020·International Journal of Molecular Sciences·Sara Balbuena-PecinoIsabel Navarro
Jul 19, 2018·Trends in Endocrinology and Metabolism : TEM·Almudena Veiga-LopezVasantha Padmanabhan
Jun 28, 2019·Environmental Science & Technology·Min-Chul LeeJae-Seong Lee

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