Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding

Journal of Immunology Research
Bryan GlueckGail A Cresci

Abstract

Excessive ethanol consumption causes adverse effects and contributes to organ dysfunction. Ethanol metabolism triggers oxidative stress, altered immune function, and gut dysbiosis. The gut microbiome is known to contribute to the maintenance of intestinal homeostasis, and disturbances are associated with pathology. A consequence of gut dysbiosis is also alterations in its metabolic and fermentation byproducts. The gut microbiota ferments undigested dietary polysaccharides to yield short-chain fatty acids, predominantly acetate, propionate, and butyrate. Butyrate has many biological mechanisms of action including anti-inflammatory and immunoprotective effects, and its depletion is associated with intestinal injury. We previously showed that butyrate protects gut-liver injury during ethanol exposure. While the intestine is the largest immune organ in the body, little is known regarding the effects of ethanol on intestinal immune function. This work is aimed at investigating the effects of butyrate supplementation, in the form of the structured triglyceride tributyrin, on intestinal innate immune responses and oxidative stress following chronic-binge ethanol exposure in mice. Our work suggests that tributyrin supplementation prese...Continue Reading

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Citations

Feb 7, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Gail A M CresciGlenn Gibson
Jun 26, 2020·Molecular Nutrition & Food Research·Bei GaoBernd Schnabl
Jul 21, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Mohamed Tausif Siddiqui, Gail A M Cresci
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nikola VrzáčkováJaroslav Zelenka
Jun 19, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Carla B P SilvaRita C Tostes
Jul 25, 2021·International Journal of Molecular Sciences·Javier Calleja-CondeJose Antonio López-Moreno

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay

Software Mentioned

Prism
Image Pro Plus
GraphPad

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