Tricalcium Silicate Capping Materials Modulate Pulp Healing and Inflammatory Activity In Vitro

Journal of Endodontics
Thomas GiraudImad About

Abstract

On stimulation by lipoteichoic acid or by a physical injury, fibroblasts have been shown to play a major role in the initiation of the pulp inflammatory reaction and healing through secretion of complement proteins and growth factors. The application of direct pulp-capping materials on these cells may interfere with the inflammatory and the healing processes within the pulp's inextensible environment. This work was designed to study in vitro the effects of silicate-based materials on pulp fibroblast modulation of the initial steps of pulp inflammation and healing. The effects of Biodentine, TheraCal, and Xeno III eluates were studied on lipoteichoic acid-stimulated and physically injured fibroblasts. Cytokine secretion (interleukin 6, vascular endothelial growth factor, fibroblast growth factor-2, and transforming growth factor-β1) was quantified by enzyme-linked immunosorbent assay. Inflammatory THP-1 adhesion to endothelial cells and their migration and activation were studied in vitro. Human pulp fibroblast proliferation was investigated with the MTT test, and their migration to the injury site was studied with the scratch healing assay. Interleukin 6 and vascular endothelial growth factor secretion increased with all materi...Continue Reading

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Citations

Mar 28, 2020·International Journal of Molecular Sciences·Katarzyna BarczakJadwiga Buczkowska-Radlińska
Mar 12, 2020·Materials·Marta Kunert, Monika Lukomska-Szymanska
Sep 21, 2020·Journal of Endodontics·Chloé Le FournisImad About
Jun 5, 2019·Journal of Endodontics·Charlotte JeanneauImad About
Apr 16, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Sergio López-GarcíaDavid García-Bernal
May 5, 2021·Journal of Biomaterials Science. Polymer Edition·Matthew J Osmond, Melissa D Krebs
May 27, 2021·Journal of Dental Research·N S RodriguesL E Bertassoni
Oct 3, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Thomas GiraudImad About
Jun 29, 2021·Journal of Endodontics·Chloé Le FournisImad About
Oct 3, 2021·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Naoki EdanamiYuichiro Noiri

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