Tricarbonyldichlororuthenium(II) dimer, the lipid-soluble carbon monoxide-releasing molecule, attenuates Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-1β in murine macrophages.

International Immunopharmacology
Eun-Young ChoiSung-Jo Kim

Abstract

Carbon monoxide (CO) is increasingly being appreciated as an important mediator that has pleiotropic biological properties and appears to have a possible therapeutic application for a variety of disorders. Nevertheless, whether this gaseous molecule may be utilized as a therapeutic intervention for periodontal disease is unclear. Here, we examined the potential beneficial effect of CO-releasing molecule-2 (CORM-2), a tricarbonyldichlororuthenium(II) dimer, against the elaboration of proinflammatory mediators by murine macrophages challenged with lipopolysaccharide (LPS) isolated from Prevotella intermedia, a pathogenic bacterium implicated in inflammatory periodontal disease. We found that NO and IL-1β production, iNOS protein expression and mRNA expressions of iNOS and IL-1β were significantly down-regulated when LPS-challenged RAW264.7 cells were exposed to CORM-2. In addition, HO-1 expression was upregulated by CORM-2 in cells activated with P. intermedia LPS, and the inhibitory influence of CORM-2 upon NO production was attenuated by tin protoporphyrin IX, an inhibitor of HO activity. PPAR-γ did not function in the attenuation of NO and IL-1β by CORM-2. JNK and p38 phosphorylation caused by LPS was not altered by CORM-2. CO...Continue Reading

References

Aug 1, 1991·Journal of Clinical Periodontology·U ZappaM Espeland
Aug 1, 1991·Journal of Clinical Periodontology·P StashenkoS S Socransky
Feb 8, 1990·The New England Journal of Medicine·R C Williams
May 1, 1987·Journal of Clinical Immunology·E D StoufiP P Stashenko
Mar 1, 1980·Journal of Periodontal Research·K S Kornman, W J Loesche
Sep 1, 1983·Journal of Periodontology·C P ChungR J Genco
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K D Poss, S Tonegawa
Jan 8, 1999·Journal of Periodontal Research·M MatejkaH Sinzinger
Jun 3, 2000·Annual Review of Immunology·M Karin, Y Ben-Neriah
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·J T ChapmanA M Choi
Feb 9, 2002·Circulation Research·Roberto MotterliniColin J Green
Feb 28, 2002·Science's STKE : Signal Transduction Knowledge Environment·D M Rothwarf, M Karin
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Danielle Morse, Augustine M K Choi
Jul 15, 2003·The Journal of Biological Chemistry·Danielle MorseAugustine M K Choi
Aug 12, 2003·Trends in Immunology·Leo E OtterbeinFritz H Bach
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Istvan BakArpad Tosaki
Feb 28, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stefan W Ryter, Leo E Otterbein
Aug 26, 2004·Oral Microbiology and Immunology·J J KammaP C Baehni
Sep 24, 2004·Current Pharmaceutical Design·E PfitznerC M Litterst
Sep 13, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Judit K Sarady-AndrewsLeo E Otterbein
Nov 1, 2005·Expert Opinion on Investigational Drugs·Roberto MotterliniRoberta Foresti
Feb 24, 2006·Nature Reviews. Immunology·Christopher K Glass, Sumito Ogawa
Apr 8, 2006·Physiological Reviews·Stefan W RyterAugustine M K Choi
Apr 11, 2006·The Journal of Pharmacology and Experimental Therapeutics·Philip SawleRoberto Motterlini
Apr 17, 2007·Biochimica Et Biophysica Acta·Mercedes Ricote, Christopher K Glass
Sep 3, 2010·Nature Reviews. Drug Discovery·Roberto Motterlini, Leo E Otterbein
Sep 14, 2010·Journal of Applied Oral Science : Revista FOB·Cyntia Rodrigues de Araújo EstrelaCarlos Estrela

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