Trichilemmal Cysts With Divergent Ductal Differentiation: A Series of 4 Cases.

The American Journal of Dermatopathology
Irfan KhanHongyan Dai

Abstract

Trichilemmal cysts are common clonal tumors with a predilection for the scalp. They are composed of an outer epithelial wall resembling the outer root sheath in the isthmus of the hair follicle and a central core of compact keratin. Sweat duct differentiation is exceptional with only one convincing case reported to date. Here, we sought to characterize the clinicopathological characteristics of sweat duct differentiation in trichilemmal cysts. We reviewed all cases of trichilemmal cyst diagnosed at our institution between 2008 and 2019. Ductal structures were found in 4 of 411 cases (0.97%). Subjects included 2 male and 2 female patients with a median age of 37.5 years (range 34-55). The ducts were lined by attenuated epithelial cells and immunoreactive for polyclonal carcinoembryonic antigen and cytokeratin 7. Ductal differentiation involved a median of 7.5% (range 1%-50%) of the cyst wall. All 4 cases were from the scalp and treated with local excision. No recurrence was identified with a median follow-up period of 1.5 years (range 1-12 years). In summary, sweat duct differentiation in trichilemmal cysts is rare but likely under recognized. Conceptually, we suggest it represents a type of divergent cellular differentiation wi...Continue Reading

References

Jun 1, 1991·The American Journal of Dermatopathology·L Requena, E Sánchez Yus
Sep 1, 1980·Clinical and Experimental Dermatology·D Hanau, E Grosshans
Feb 1, 1995·The American Journal of Dermatopathology·K EgawaT Ono
Apr 1, 1995·The British Journal of Dermatology·K EgawaE M De Villiers
Mar 1, 1994·Journal of the American Academy of Dermatology·K EgawaE M de Villiers
Aug 1, 1996·The American Journal of Dermatopathology·W K AndersenJ Bhawan
Feb 22, 2012·The American Journal of Dermatopathology·Elena González-GuerraLuis Requena
Feb 7, 2014·Journal of Cutaneous Pathology·Shinichi KobaYutaka Narisawa
Jul 15, 2015·Molecular Medicine Reports·Qiao LiuFeng Qiao
Nov 21, 2015·The American Journal of Dermatopathology·Vanda F TorousSeong H Ra
Oct 30, 2016·Journal of Cutaneous Pathology·Kayhan Başak, Pınar Y Başak
Sep 22, 2017·International Journal of Trichology·Krishnendu Mondal, Rupali Mandal
Sep 25, 2017·The American Journal of Dermatopathology·Ray-San ChangYu-Hung Wu
May 15, 2019·The Journal of Investigative Dermatology·Steffen HörerJudith Fischer

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