Trichilemmoma arising in the nasal vestibule: report of three cases with special emphasis on the differential diagnosis

Head and Neck Pathology
Marisa HerráizJuan C Tardío

Abstract

Trichilemmoma is a benign cutaneous epithelial tumor with differentiation towards cells of the outer hair root sheath and usually presents as a small papule on the face of middle-aged or older adults. We herein report three cases of trichilemmoma located in the nasal vestibule, including two of the conventional type and one of the desmoplastic variant. To our knowledge, only one case of trichilemmoma arising in the nasal vestibule has been previously reported. Trichilemmoma must be included in the differential diagnosis of epithelial lesions arising in this location. This is particularly important in the case of the desmoplastic trichilemmoma, a tumor that resembles invasive carcinoma such as desmoplastic squamous cell carcinoma, sclerosing basal cell carcinoma, and trichilemmal carcinoma. The circumscription of the lesion, the architectural pattern of epithelial cell cords and small nests merging with a desmoplastic stroma in the central area of the tumor, the expression of CD34, and the lack of an obvious squamous differentiation or basaloid foci favor the diagnosis of desmoplastic trichilemmoma. All these features help to rule out the diagnosis of carcinoma with significant clinical implications.

References

Jun 1, 1979·The British Journal of Dermatology·M H BrownsteinJ C Patterson
Jun 1, 1991·Journal of Cutaneous Pathology·C L LeonardiN S Penneys
Apr 1, 1991·The Journal of Laryngology and Otology·J A McGlashanD A Bowdler
Feb 1, 1990·Journal of Cutaneous Pathology·S J HuntD J Santa Cruz
Jun 1, 1973·Archives of Dermatology·M H Brownstein, L Shapiro
Jan 1, 1980·The American Journal of Dermatopathology·A B Ackerman, T R Wade
Jun 1, 1994·Journal of Cutaneous Pathology·E PobletA Rocamora
Jan 1, 1996·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D J Halvorson, F A Kuhn
Nov 24, 1998·Journal of Cutaneous Pathology·C IlluecaA Llombart-Bosch
Oct 1, 1962·Archives of Dermatology·J T Headington, A J FRENCH
Nov 7, 2006·American Journal of Otolaryngology·Jeffrey H Spiegel, Naghmeh Khodai
Jan 8, 2009·Journal of Cutaneous Pathology·Juan C Tardío
Jul 21, 2009·Journal of Cutaneous Pathology·Sarah StiermanJean Thomas
Aug 1, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Andrea Bolzoni VillaretAlfred Aga

Citations

Nov 26, 2015·Journal of Clinical Pathology·Richard DanialanDoina Ivan
Feb 3, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·A K JhaR Sinha
Jul 16, 2019·The Journal of International Medical Research·Shan ZhongXue-Ling Mei

Related Concepts

Carcinomatosis
Differential Diagnosis
Cancer of Nose
Neoplasms, Adnexal and Skin Appendage
Hair Follicle Structure
Carcinoma
Squamous Cell Carcinoma
Cell Differentiation Process
Epithelial Cells
Face

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