Trichinella spiralis: macrophage activity and antibody response in chronic murine infection

Experimental Parasitology
Marta Kołodziej-SobocińskaE Dziemian

Abstract

The role of macrophages, their products, and the specific antibody response were examined during chronic Trichinella spiralis infection in BALB/c mice. Adult T. spiralis in intestines were detected from 5 to 20 dpi. Muscle larvae numbers peaked at 45 dpi and thereafter a reduction was noted. The highest numbers of macrophages in the peritoneal cavity of infected mice were obtained up to 30 dpi. The production of NO by macrophages in infected mice was suppressed at 5 dpi, and then NO release increased until 45 dpi. The levels of NO in plasma and urine were lower in infected mice during the entire experiment in comparison to control. The production of O(2)(-) in peritoneal macrophages was inhibited during the first two weeks after infection and then increased until 90 dpi. Circulating T. spiralis antigens in plasma and urine were detected from 5 to 30 dpi. Specific IgM and IgA in serum increased until 20 dpi. IgG, IgG(1), and IgG(2) levels in serum increased until 60 dpi.

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Citations

Mar 30, 2007·Parasitology Research·Marta Kołodziej-SobocińskaB Machnicka-Rowińska
Nov 21, 2007·Biochemical and Biophysical Research Communications·Jing YangXinping Zhu
Jun 2, 2011·Experimental Parasitology·Dalia S Ashour, Reda H Elbakary
Jun 18, 2017·Frontiers in Immunology·Limei ZhaoXinping Zhu
Apr 27, 2020·Veterinary Parasitology·Nan WangXiaolei Liu

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Antigens, Helminth
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