Abstract
Two strains of mice which share identical H-2 genes but differ in their genetic backgrounds were compared for their ability to resist infection with Trichinella spiralis. The two strains of mice, C3HeB/FeJ and AKR/J, share the H-2k haplotype which is associated with susceptibility to primary infection with T. spiralis in H-2 congenic strains of mice. AKR/J mice, infected with 150 infective muscle larvae, harbored significantly fewer muscle larvae 30 days postinfection than did mice of the strain C3HeB/FeJ. Approximately equal numbers of worms establish in the small intestine of AKR and C3H mice, but the AKR mice expelled adult worms from the gut more rapidly than did mice of the C3H strain. By Day 9 postinfection, 50% of the worms had been expelled by the AKR mice whereas expulsion of worms from C3H mice was delayed beyond Day 9 and occurred primarily between Days 10 and 12. Over this same experimental period (Days 6-12), fecundity of female worms from AKR mice, measured as the mean newborn larvae/female/hour, was approximately one-half that of worms taken from C3H mice. These results support the conclusion that genes outside of the mouse H-2 complex regulate expulsion of adult worms from the gut. These background genes also ma...Continue Reading
Citations
Jan 1, 1983·Immunogenetics·C J KrcoC S David
Jan 1, 1991·Parasitology Research·E SciuttoC Larralde
Feb 9, 2006·Immunogenetics·Tohru SuzukiMamoru Terada
Aug 5, 2008·Parasitology Research·Tohru SuzukiKeiji Ueda
Dec 1, 1984·Experimental Parasitology·R G BellR W Ogden
Jun 1, 1988·Experimental Parasitology·R G Bell
Nov 1, 1992·International Journal for Parasitology·J M BehnkeD Wakelin
May 1, 1984·Veterinary Immunology and Immunopathology·H R Miller
Jan 1, 1987·Immunology Today·D L WassomC S David
Jan 1, 1989·International Journal of Immunopharmacology·B E JohnsonD L Wassom
Jan 1, 1992·Toxicology·R W LuebkeR J Smialowicz
Jul 29, 1998·Comparative Immunology, Microbiology and Infectious Diseases·F BozićD Stojcević
Jun 1, 1988·Parasitology·K Else, D Wakelin
Dec 12, 2012·Virulence·Rhiannon R White, Katerina Artavanis-Tsakonas
Jun 10, 2009·Journal of Microbiological Methods·Elzbieta GolabAleksander Masny
Aug 30, 2008·Trends in Parasitology·Fabrizio BruschiNaohiro Watanabe
Mar 1, 1986·Parasite Immunology·D WakelinR K Grencis
Oct 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M I FergusonP S Collier