PMID: 3754680Feb 1, 1986Paper

Trichloroacetic acid accumulates in murine amniotic fluid after tri- and tetrachloroethylene inhalation

Acta Pharmacologica Et Toxicologica
H GhantousO Vesterberg

Abstract

The distribution of trichloroethylene (Tri) and tetrachloroethylene (Tetra) and their metabolites have been studied in pregnant mice by means of whole-body autoradiography (14C-labelled Tri and Tetra) and gas chromatography, with special emphasis on possible uptake and retention in the foetoplacental unit. Volatile (non-metabolized) activity appeared at short intervals after a 10 min. or 1 hr inhalation period in foetus and amniotic fluid. Most notable, however, was a strong accumulation and retention (peak at 4 hrs) in amniotic fluid of the metabolite trichloroacetic acid (TCA) after inhalation of either of the solvents. The main metabolite of Tri, trichloroethanol (TCE) (or conjugates), did not accumulate specifically as compared to maternal plasma. TCA infused intravenously in the maternal plasma was accumulated in amniotic fluid, but less pronounced than after Tri and Tetra inhalation, indicating that some metabolism of Tri and Tetra to TCA may occur in the foetoplacental unit. The results suggest that TCA may be transported to the foetus partly paraplacentally through foetal membranes and amniotic fluid, with the possibility of foetal swallowing or absorption through the skin. Foetal urinary activity also suggests that cir...Continue Reading

References

Dec 1, 1979·Toxicology and Applied Pharmacology·D G PeggP G Watanabe
Mar 1, 1977·Scandinavian Journal of Work, Environment & Health·B HolmbergK Sigvardsson
Dec 1, 1975·Scandinavian Journal of Work, Environment & Health·O VesterbergM Krasts
Jan 1, 1972·Archiv Für Toxikologie·G MüllerD Henschler
Nov 1, 1984·Acta Pharmacologica Et Toxicologica·B R DanielssonL Dencker
Mar 1, 1982·British Journal of Anaesthesia·T E HealyA Hopper
Jan 1, 1950·Anaesthesia·P J HELLIWELL, A M HUTTON
Jan 1, 1949·Anaesthesia·P J HELLIWELL, A M HUTTON

❮ Previous
Next ❯

Citations

Feb 24, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Royana Singh
Nov 18, 2014·Expert Review of Clinical Immunology·Nara Tagiyeva, Aziz Sheikh
Dec 31, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Rebecca Brown DzubowStanley Barone
Feb 1, 1991·Pharmacology & Toxicology·T Kyrklund, K Haglid
Aug 14, 1998·Environmental Health Perspectives·P D JohnsonS J Goldberg
Jul 13, 2005·Archives of Toxicology·Cristina DiodovichLaura Gribaldo
Feb 6, 2020·Environmental Science. Processes & Impacts·Elana R ElkinRita Loch-Caruso
Nov 1, 1989·Teratology·M K SmithJ A Stober
Jun 18, 2020·Frontiers in Physiology·Sean M HarrisRita Loch-Caruso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.