PMID: 11926613Apr 3, 2002Paper

Trichloroethylene induced testicular toxicity in rats exposed by inhalation

Human & Experimental Toxicology
P KumarK K Dutta

Abstract

Trichloroethylene (TCE) is an organic solvent used in dry cleaning, metal degreasing, thinner for paints and varnishes, anesthetic agent, and so forth. Human beings are appreciably exposed to TCE vapours by inhalation route. The present study has been undertaken to investigate whether TCE inhalation may also bring about testicular toxic effects. Our results indicate that inhalation of TCE by male rats for 12 and 24 weeks brings about significant reduction in absolute testicular weight, and alters marker testicular enzymes activity associated with spermatogenesis and germ cell maturation, along with marked histopathological changes showing depletion of germs cells and spermatogenic arrest.

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Citations

Jan 1, 2012·Journal of Environmental Sciences (China)·Badar GhauriChristian Khalil
Jan 23, 2004·Biology of Reproduction·Shelley Brown DuTeauxMarion G Miller
Aug 27, 2013·Pharmacology & Therapeutics·Ivan RusynKathryn Z Guyton
Sep 19, 2006·Reproductive Toxicology·Bayram YilmazHaluk Kelestimur
Apr 23, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Kyungsil YoonByung-Mu Lee
Dec 15, 2006·Ecotoxicology and Environmental Safety·U ManiR C Murthy
Aug 7, 2009·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Shams Tabrez, Masood Ahmad

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