Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors

Journal of the American Academy of Dermatology
Iakov ShimanovichChristian Rose

Abstract

Trichoadenoma is a rare benign follicular tumor first described by Nikolowski 50 years ago. Both trichoadenoma and desmoplastic trichoepithelioma are composed of cords of epithelial cells and cornifying cysts embedded in sclerotic stroma. In trichoadenoma the cystic component predominates, while desmoplastic trichoepithelioma is a mostly solid neoplasm. Therefore trichoadenoma was suggested to represent a cystic variant of desmoplastic trichoepithelioma. The aim of this study was to investigate whether the morphologic overlap between trichoadenoma and desmoplastic trichoepithelioma translates into a similar immunohistochemical profile. We studied 19 trichoadenomas and 21 desmoplastic trichoepitheliomas for cytokeratin 20, Ber-EP4, and androgen receptor expression. Eighteen of 19 trichoadenomas and all desmoplastic trichoepitheliomas demonstrated the presence of Merkel cells as detected by a monoclonal antibody against cytokeratin 20. In contrast, while all desmoplastic trichepitheliomas were positive for Ber-EP4, only 4 of 19 trichoadenomas showed any kind of reactivity for this marker. None of the trichoadenomas or desmoplastic trichoepitheliomas expressed androgen receptor. This study is limited by the moderate number of thes...Continue Reading

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Citations

Sep 23, 2011·The American Journal of Dermatopathology·Noriyuki MisagoYutaka Narisawa
Feb 11, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Teresa O Matos, Fred H Linthicum
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May 7, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Angel Fernandez-Flores, David S Cassarino
Jul 17, 2020·The Australasian Journal of Dermatology·Juan Francisco Mir-BonaféFernando Terrasa-Sagristà
Apr 23, 2019·The American Journal of Dermatopathology·Simon F RoySergio González Bombardiere

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