Abstract
Three cases of trichoblastic fibroma, a rare benign skin tumor of hair follicle origin, are reported. On clinical examination, solitary, mobile, subcutaneous nodules with normal overlying skin were found on the vulva (one case) and scalp (two cases) in women aged 57, 46, and 19 years, respectively. On microscopic examination, the tumors were composed of complex nests and strands of basaloid, focally keratinized epithelium arranged in a moderately cellular fibroblastic stroma. No connection with the overlying epithelium or adjacent adnexal structures was observed. Immunohistochemical staining supported a trichogenic origin for these tumors. Trichoblastic fibromas are histologically distinctive lesions that should be distinguished from other tumors of follicular origin and from keratotic basal cell carcinoma.
Citations
Aug 5, 2000·Annals of Diagnostic Pathology·C WilsonT W Mesko
Apr 24, 1999·The British Journal of Dermatology·O Yamamoto, M Asahi
Jun 8, 2000·Histopathology·T W Shek
Aug 1, 1997·The American Journal of Dermatopathology·C G SchirrenW H Burgdorf
Oct 27, 1999·The American Journal of Dermatopathology·S A MeehanR V Rouse
Mar 16, 2005·The American Journal of Surgical Pathology·Sigrid Regauer, Francisco F Nogales
Jan 1, 1997·Pathology International·M FukunagaS Ushigome
Aug 20, 2009·Pediatric Dermatology·Tae Wook KangYoung Min Park
Dec 29, 2010·Journal of Cytology·Jayashree Krishnamurthy, Kn Divya
Apr 4, 2015·South Asian Journal of Cancer·Bhavuray TeliShravan Rajpurohit
Jun 18, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·G A PeterdyA C Lind
Dec 1, 1990·Journal of Cutaneous Pathology·L RequenaA de Castro
Apr 1, 1993·Journal of Cutaneous Pathology·O YamamotoM Asahi
Oct 1, 1992·Journal of Cutaneous Pathology·P SauJ H Graham
Jun 1, 1993·Histopathology·T Y WongM C Mihm