Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus

Journal of Cutaneous Pathology
Emilie DoreBrian L Swick

Abstract

Herein, we describe a 63-year-old male with multiple tumors arising within a nevus sebaceus on the posterior scalp. On histopathologic examination, four distinct tumors were identified: trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum (TFI). Within the TFI component of the nevus sebaceus, there was intracytoplasmic accumulation of eosinophilic keratin, as shown on pancytokeratin-stained sections, imparting a signet-ring appearance to the cells. To our knowledge, this is the first report of signet-ring cells arising within a TFI occurring in a nevus sebaceus. We discuss this case as well as review the literature on multiple tumors arising within nevus sebaceus and signet-ring cell changes in primary cutaneous tumors.

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Citations

Jul 16, 2019·The Journal of International Medical Research·Shan ZhongXue-Ling Mei
Jul 30, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ximena WortsmanYamile Corredoira
Jan 25, 2018·Anais Brasileiros De Dermatologia·Márcio Martins Lobo JardimRafael Cavanellas Fraga
Mar 24, 2018·Indian Journal of Pathology & Microbiology·Feifei WangYanping Bai

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