Trichomonas vaginalis Transports Virulent Mycoplasma hominis and Transmits the Infection to Human Cells after Metronidazole Treatment: A Potential Role in Bacterial Invasion of Fetal Membranes and Amniotic Fluid

Journal of Pregnancy
Tran Thi Trung ThuPier L Fiori

Abstract

Mycoplasma hominis is considered an opportunistic pathogen able to colonize the lower urogenital tract; in females the infection is associated with severe pregnancy and postpartum complications, including abortion, endometritis, preterm delivery, and low birth weight. Molecular mechanisms of pathogenicity and virulence effectors remain poorly characterized. A number of studies in the last decade have demonstrated that M. hominis can establish an endosymbiotic relationship with Trichomonas vaginalis, a urogenital parasitic protozoon, also associated with adverse pregnancy outcomes. Recently, two bacterial genes (alr and goiB) associated with amniotic cavity invasion and a single gene (goiC) associated with intra-amniotic infections and high risk of preterm delivery have been identified in M. hominis isolated from a group of pregnant patients. In this work we demonstrate that a high number of M. hominis intracellularly associated with T. vaginalis have goiC gene, in association with alr and goiB. In addition, we demonstrate that metronidazole treatment of M. hominis-infected T. vaginalis allows delivering viable intracellular goiC positive M. hominis from antibiotic-killed protozoa and that free M. hominis can infect human cell c...Continue Reading

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Citations

Jan 9, 2019·Parasitology·Daniele DessìPaola Rappelli
Sep 25, 2019·Medical Sciences : Open Access Journal·Aruna Kumari DivakaruniSrinivas Divakaruni
May 28, 2020·Frontiers in Cellular and Infection Microbiology·Valentina MargaritaPaola Rappelli
Sep 18, 2020·Pathogens and Disease·Saman SaadatMohammad Yousef Alikhani
Dec 1, 2021·Recent Advances in Anti-infective Drug Discovery·Mykola YasynetskyiAndrii Borzhievskyy

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Methods Mentioned

BETA
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Infection

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