Abstract
Lung cancer is the leading cause of cancer-related death worldwide. Non-small cell lung cancer (NSCLC) accounts for 80% of lung cancer cases and the reported overall 5-year survival rate is less than 5%. Natural medicines have attracted much attention due to their lower toxicity and fewer side effects. Trichosanthes kirilowii Maxim (TKM) fruits are commonly used in cancer treatment in combination with other Chinese medicinal herbs. However, little is known about their biological functions and mechanisms in NSCLC cells. In this study, we investigated the efficacy of TKM fruits in NSCLC cells using cell proliferation, invasion, migration, and anchorage independent assays and a Xenograft NSCLC tumor model, and explored the possible biological mechanism by flow cytometric analysis, cDNA microarray and real-time PCR. Results showed that TKM fruits significantly suppressed NSCLC cell proliferation, migration, invasion, tumorigenicity and tumor growth, and significantly extended the survival time of NSCLC-bearing mice. Flow cytometric analysis showed that TKM fruits significantly induced G2-M arrest, necrosis and apoptosis in NSCLC cells. cDNA microarray analysis revealed that TKM fruits regulated the differential expression of 544 ge...Continue Reading
References
Feb 9, 1990·Cell·J GautierJ L Maller
May 5, 1989·Cell·K RiabowolD Beach
Apr 5, 2000·The Journal of Biological Chemistry·S JinQ Zhan
Aug 11, 2001·The Journal of Biological Chemistry·O KovalskyA J Fornace
Jan 6, 2006·Biological & Pharmaceutical Bulletin·Eun-Ok LeeSung-Hoon Kim
Jan 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael McCullochJohn M Colford
May 8, 2009·Cancer Chemotherapy and Pharmacology·Barrie R CassilethMark G Kris
Apr 21, 2010·The Journal of Cell Biology·Arne Lindqvist
May 18, 2010·Journal of Natural Products·Nguyen Tien DatJung Joon Lee
Aug 14, 2010·Cell·Michael J MoorePamela A Silver
Apr 14, 2011·Cancer Research·John BrognardTony Hunter
Mar 1, 2012·PloS One·Toran SanliGurmit Singh
Jul 11, 2012·Toxicology International·Sagar L ShahSubhash L Bodhankar
Sep 18, 2012·Cellular Signalling·Xiao-Yue ZhangXiao-Feng Zhu
Dec 15, 2012·Cell Death and Differentiation·I Ben-SahraF Bost
Jan 22, 2013·PloS One·Hsin-Yi ChangSi-Chen Lee
Jul 31, 2013·The American Journal of Chinese Medicine·Jinsoo LeeSeong Ha Cheon
Oct 10, 2013·Advances in Experimental Medicine and Biology·Jesús M SalvadorAlbert J Fornace
Dec 19, 2013·Case Reports in Oncology·Dong-Hyun LeeJae-Bok Han
Citations
Sep 16, 2016·The American Journal of Chinese Medicine·Xiao-Li DongHao-Tian Feng
Oct 18, 2016·The American Journal of Chinese Medicine·Shu-Jing YuQi-Hui Zhang
Nov 5, 2016·The American Journal of Chinese Medicine·Feng SuiTing-Liang Jiang
Jan 20, 2017·BMC Complementary and Alternative Medicine·Hsin-Yi LoTin-Yun Ho
Feb 14, 2019·Thoracic Cancer·Xiaoying GuanYajie Zhang
Aug 19, 2016·Oncotarget·Youn Kyung ChoiSeong-Gyu Ko
Nov 9, 2017·Molecular Medicine Reports·Ji-Hye JooEunmi Choi
Apr 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huang-Qin ZhangWei-Wen Li
Feb 25, 2017·The American Journal of Chinese Medicine·Ling JinXiao-Feng Zhu
Apr 2, 2016·Molecular Medicine Reports·Ying FangYajie Zhang
Jul 24, 2020·Anti-cancer Drugs·Lulu NiLiying Qiu
Oct 17, 2020·Chinese Medical Journal·Xiao-Lin SuQiu-Hong Wang
Apr 8, 2021·Cancer Chemotherapy and Pharmacology·Min LiuZhicheng Gong
Oct 17, 2020·Anti-cancer Drugs·Lulu NiLiying Qiu
Sep 22, 2020·Complementary Therapies in Medicine·Ming-Hsien YehTe-Mao Li