Trichosporon inkin as an Emergent Pathogen in Patients With Severe Pemphigus

JAMA Dermatology
João Nobrega de Almeida JúniorGil Benard

Abstract

To our knowledge, these are the first reports of bloodstream infections by Trichosporon inkin in patients with pemphigus. Trichosporon inkin, a novel organism causing bloodstream infection, was detected in 2 patients with pemphigus. An elderly man with pemphigus foliaceus died despite treatment with liposomal amphotericin B, 3 mg/kg/d, and a young girl with pemphigus vulgaris responded to treatment with voriconazole, 8 mg/kg/d, for 24 days. One of the T inkin isolates had a minimal inhibitory concentration of 2 mg/L against amphotericin B, suggesting resistance to the drug. Delayed suspicion of invasive infection by T inkin may result in a poor outcome in patients with severe forms of pemphigus. This opportunistic infection is highly refractory to conventional potent antifungal treatment.

Citations

Nov 2, 2016·Frontiers in Microbiology·João N de Almeida Júnior, Christophe Hennequin
Sep 20, 2018·BMC Infectious Diseases·Eveline Pipolo MilanGuilherme Maranhão Chaves

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