Trichosporonosis in a tertiary care cancer center: risk factors, changing spectrum and determinants of outcome

Scandinavian Journal of Infectious Diseases
D P KontoyiannisI Raad

Abstract

To assess the spectrum and outcome of trichosporonosis (TS) in cancer patients, we reviewed the medical records of 17 such patients with TS. TS presented most commonly as fungemia (n = 10, including 7 with central-venous-catheter-related infection) and either pulmonary or soft tissue infection (n = 3, each). Most patients (65%) had acute leukemia, 11 (65%) had neutropenia, and 9 (53%) had received high doses of corticosteroids. 10 patients had breakthrough TS during therapy with at least 1 of the following: amphotericin B, fluconazole, itraconazole, and voriconazole. The 30-d crude mortality rate was 53%. Predictors of mortality by using univariate analysis included: high median APACHE II score (p < 0.01), use of high dose of corticosteroids (p = 0.01), and admission to the intensive care unit (p < 0.01). TS is associated with a high mortality rate in cancer patients. The spectrum of infection at our institution has shifted from a predominance of disseminated infection to CVC-related fungemias without evidence of tissue invasion.

References

Nov 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E AnaissieG Bodey
Mar 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I SurmontM Boogaerts
Jul 1, 1990·Journal of Clinical Microbiology·T J WalshP A Pizzo
Nov 1, 1986·Reviews of Infectious Diseases·J HoyG P Bodey
Jan 1, 1994·Mycoses·E GuéhoB Dupont
Mar 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H Rex
Dec 1, 1996·Journal of Chemotherapy·K PerparimM Nasu
Feb 2, 1999·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·V KrcmeryJ Trupl
Apr 4, 2000·Bone Marrow Transplantation·B ErerG Izzi
Sep 15, 2000·Infectious Disease Clinics of North America·D P KontoyiannisG P Bodey
Mar 19, 2002·Antimicrobial Agents and Chemotherapy·Niki I PaphitouJohn H Rex
Apr 12, 2002·Lancet·Dimitrios P Kontoyiannis, Russell E Lewis
Dec 20, 2002·The New England Journal of Medicine·Jorge Mora-DuarteUNKNOWN Caspofungin Invasive Candidiasis Study Group
Jan 15, 2003·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S FournierJ M Molina

❮ Previous
Next ❯

Citations

Jan 31, 2009·Medical Mycology·Gisele M Duboc De AlmeidaMarcelo N Burattini
Jul 20, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcio Nucci, Kieren A Marr
Feb 16, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kosei MatsueMasami Takeuchi
Oct 7, 2011·Clinical Microbiology Reviews·Arnaldo L ColomboGuilherme M Chaves
Aug 7, 2009·Journal of Clinical Microbiology·Patrick W HickeyThomas J Walsh
May 30, 2013·BMC Infectious Diseases·Masaki YamamotoSatoshi Ichiyama
Jan 22, 2010·Critical Reviews in Microbiology·Michael A Pfaller, Daniel J Diekema
May 4, 2010·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Shih-Ta ShangMing-Yieh Peng
Nov 22, 2011·The Journal of Infection·Maria N ChitasombatDimitrios P Kontoyiannis
Feb 15, 2011·Infectious Disease Clinics of North America·George J Alangaden
Jan 29, 2011·The Lancet Infectious Diseases·Marisa H MiceliSamuel A Lee
Nov 14, 2015·Open Forum Infectious Diseases·Yong LiaoRongya Yang
Nov 19, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K HosokawaS Nakao
Jan 12, 2010·European Journal of Haematology·Kei SuzukiNaoyuki Katayama
Jan 5, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J N Almeida JúniorC Hennequin
Aug 16, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Deniz Yilmaz KarapinarYeşim Aydinok
Oct 19, 2013·International Journal of Dermatology·Malini R CapoorV Ramesh
Feb 18, 2012·International Journal of Antimicrobial Agents·Nikolaos V Sipsas, Dimitrios P Kontoyiannis
Dec 21, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J N de Almeida JúniorC Hennequin
May 31, 2006·Expert Opinion on Pharmacotherapy·Gulsen Ozkaya Sahin, Murat Akova
Jun 25, 2015·BioMed Research International·Laura Elena Carreto-BinaghiMaria Lucia Taylor
Apr 9, 2015·Medical Mycology·Yong LiaoRongya Yang
Oct 10, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C ArendrupUNKNOWN European Confederation of Medical Mycology
Nov 2, 2014·PloS One·Isabel Antonieta Iturrieta-GonzálezArnaldo Lopes Colombo
Nov 2, 2016·Frontiers in Microbiology·João N de Almeida Júnior, Christophe Hennequin
Jan 19, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Anupam PandeCarlos A Q Santos
Sep 6, 2007·Virchows Archiv : an International Journal of Pathology·Makoto SanoNorimichi Nemoto
Apr 11, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M TreviñoM Cuenca-Estrella
Dec 3, 2016·Therapeutic Advances in Hematology·Markus Ruhnke, Stefan Schwartz
Nov 21, 2017·F1000Research·Anna SkiadaMaria Drogari-Apiranthitou
Aug 11, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C RiegerH Ostermann
Mar 20, 2010·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·UNKNOWN Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (RKI)
Jun 1, 2009·Expert Review of Hematology·Jane A Cecil, Richard P Wenzel
Oct 28, 2011·Expert Review of Anti-infective Therapy·Morena CairaLivio Pagano
Mar 22, 2013·Japanese Journal of Infectious Diseases·Daisuke SasaiKazutoshi Shibuya
Nov 6, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A Lacasse, K O Cleveland
May 6, 2009·AIDS·Randy O OderoKerry O Cleveland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.