Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene

FEBS Letters
Tomoya YokotaToshiyuki Sakai

Abstract

We have reported that histone deacetylase (HDAC) inhibitors activate a member of the INK4 family, the p19INK4d gene, causing G1 phase arrest. We report here that HDAC inhibitor, Trichostatin A, activates another member of the INK4 family, the p18INK4c gene, through its promoter in Jurkat cells. Interestingly, the activation patterns of the p18INK4c gene were different from those of p19INK4d. Furthermore, mouse embryo fibroblasts lacking p18Ink4c or p18Ink4c/p19Ink4d were resistant to the growth inhibitory effects of TSA as compared to their wild-type counterpart. Our findings suggest that p18INK4c is involved in TSA-mediated cell growth inhibition and cooperates with p19INK4d.

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Citations

Mar 25, 2011·Environmental Health and Preventive Medicine·Tatsushi YoshidaToshiyuki Sakai
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Anat BiranYoel Kloog
Dec 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jiansheng HuangDavid A Rudnick
Mar 2, 2011·Nihon eiseigaku zasshi. Japanese journal of hygiene·Toshiyuki Sakai

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